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1. WO2012073253 - THERAPEUTIC USES OF MIRNAS/COMPOUNDS THAT ACTIVATE TUMOR SUPPRESSOR GENES/MIRNAS

Publication Number WO/2012/073253
Publication Date 07.06.2012
International Application No. PCT/IN2011/000684
International Filing Date 30.09.2011
IPC
C12N 5/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C12N 5/09 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
09Tumour cells
C12N 15/79 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
CPC
C12N 15/1135
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
1135against oncogenes or tumor suppressor genes
C12N 2310/141
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2310Structure or type of the nucleic acid
10Type of nucleic acid
14interfering N.A.
141MicroRNAs, miRNAs
Applicants
  • BOOMINATHAN, Lakshmanane [IN]/[IN]
Inventors
  • BOOMINATHAN, Lakshmanane
Priority Data
2505/CHE/201030.09.2010IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THERAPEUTIC USES OF MIRNAS/COMPOUNDS THAT ACTIVATE TUMOR SUPPRESSOR GENES/MIRNAS
(FR) UTILISATIONS THÉRAPEUTIQUES DE MICROARN/COMPOSÉS QUI ACTIVENT LES GÈNES/MICROARN SUPPRESSEURS DE TUMEUR
Abstract
(EN)
The invention illustrates how the TA-p73 and TA-p63 could function as negative regulators of invasion, metastasis, and cancer stem cells proliferation. In particular, p53 and TA-p73/ p63 appear to up regulate the expression of tumor suppressor miRNA, tumor suppressor genes and metastasis suppressors. Futher, suppressing of c-myc expression can increase the expression of tumor suppressor miRNAs/genes. Identifying small molecule compounds that simultaneously suppress oncogenes and activate tumor suppressor miRNAs/genes will aid cancer therapy.
(FR)
L'invention illustre comment les TA-p73 et TA-p63 pourraient fonctionner en tant que régulateurs négatifs de l'invasion, des métastases, et de la prolifération des cellules souches du cancer. En particulier, p53 et TA-p73/p63 semblent réguler positivement l'expression de microARN suppresseur de tumeur, de gènes suppresseurs de tumeur et de suppresseurs de métastases. De plus, la suppression de l'expression de c-myc peut augmenter l'expression de microARN/gènes suppresseurs de tumeur. L'identification de composés de petites molécules qui simultanément suppriment les oncogènes et activent les microARN/gènes suppresseurs de tumeur aidera le traitement du cancer.
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