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1. (WO2012073253) THERAPEUTIC USES OF MIRNAS/COMPOUNDS THAT ACTIVATE TUMOR SUPPRESSOR GENES/MIRNAS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/073253 International Application No.: PCT/IN2011/000684
Publication Date: 07.06.2012 International Filing Date: 30.09.2011
IPC:
C12N 5/00 (2006.01) ,C12N 5/09 (2010.01) ,C12N 15/79 (2006.01) ,A61K 48/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
09
Tumour cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
BOOMINATHAN, Lakshmanane [IN/IN]; IN
Inventors:
BOOMINATHAN, Lakshmanane; IN
Priority Data:
2505/CHE/201030.09.2010IN
Title (EN) THERAPEUTIC USES OF MIRNAS/COMPOUNDS THAT ACTIVATE TUMOR SUPPRESSOR GENES/MIRNAS
(FR) UTILISATIONS THÉRAPEUTIQUES DE MICROARN/COMPOSÉS QUI ACTIVENT LES GÈNES/MICROARN SUPPRESSEURS DE TUMEUR
Abstract:
(EN) The invention illustrates how the TA-p73 and TA-p63 could function as negative regulators of invasion, metastasis, and cancer stem cells proliferation. In particular, p53 and TA-p73/ p63 appear to up regulate the expression of tumor suppressor miRNA, tumor suppressor genes and metastasis suppressors. Futher, suppressing of c-myc expression can increase the expression of tumor suppressor miRNAs/genes. Identifying small molecule compounds that simultaneously suppress oncogenes and activate tumor suppressor miRNAs/genes will aid cancer therapy.
(FR) L'invention illustre comment les TA-p73 et TA-p63 pourraient fonctionner en tant que régulateurs négatifs de l'invasion, des métastases, et de la prolifération des cellules souches du cancer. En particulier, p53 et TA-p73/p63 semblent réguler positivement l'expression de microARN suppresseur de tumeur, de gènes suppresseurs de tumeur et de suppresseurs de métastases. De plus, la suppression de l'expression de c-myc peut augmenter l'expression de microARN/gènes suppresseurs de tumeur. L'identification de composés de petites molécules qui simultanément suppriment les oncogènes et activent les microARN/gènes suppresseurs de tumeur aidera le traitement du cancer.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)