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1. (WO2012071517) NOVEL CRYSTALLINE FORMS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/071517 International Application No.: PCT/US2011/062050
Publication Date: 31.05.2012 International Filing Date: 23.11.2011
IPC:
C07F 9/6506 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
547
Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
645
having two nitrogen atoms as the only ring hetero atoms
6503
Five-membered rings
6506
having the nitrogen atoms in positions 1 and 3
Applicants:
THAR PHARMACEUTICALS, INC. [US/US]; 730 William Pitt Way Pittsburgh, PA 15238, US (AllExceptUS)
HANNA, Mazen [GB/US]; US (UsOnly)
SHAN, Ning [SG/US]; US (UsOnly)
CHENEY, Miranda, L. [US/US]; US (UsOnly)
WEYNA, David, R. [US/US]; US (UsOnly)
IBESTER, Paul, K. [US/US]; US (UsOnly)
SUN, Xufeng [CN/US]; US (UsOnly)
Inventors:
HANNA, Mazen; US
SHAN, Ning; US
CHENEY, Miranda, L.; US
WEYNA, David, R.; US
IBESTER, Paul, K.; US
SUN, Xufeng; US
Agent:
LINDEMAN, Jeffrey, A.; J.A. Lindeman & Co., PLLC 3190 Fairview Park Drive, Suite 480 Falls Church, VA 22042, US
Priority Data:
61/458,51424.11.2010US
Title (EN) NOVEL CRYSTALLINE FORMS
(FR) NOUVELLES FORMES CRISTALLINES
Abstract:
(EN) Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans. The present disclosure is directed towards generating new forms of zoledronic acid, which have the therapeutic efficacy of zoledronic acid discussed above, with improved aqueous solubility, rate of dissolution, and/or improved permeability and thus enhanced bioavailability. One aspect of the present disclosure includes novel molecular complexes of zoledronic acid that includes cocrystals, salts, and solvates (e.g. hydrates and mixed solvates as well as solvates of salts), and mixtures containing such materials. In addition, the disclosure further includes methods for the preparation of such complexes.
(FR) L'invention concerne la préparation et la caractérisation de nouvelles formes de l'acide (1-hydroxy-2-imidazol-1-yl-1-phosphono-éthyl) phosphonique, convenant à des compositions pharmaceutiques dans des systèmes d'administration de médicament pour l'homme.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20130316982