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1. WO2012071414 - QUINOXALINE COMPOUNDS AND USES THEREOF

Publication Number WO/2012/071414
Publication Date 31.05.2012
International Application No. PCT/US2011/061848
International Filing Date 22.11.2011
IPC
C07D 241/44 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
36condensed with carbocyclic rings or ring systems
38with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
40Benzopyrazines
44with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
C07D 405/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 409/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 241/42 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
36condensed with carbocyclic rings or ring systems
38with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
40Benzopyrazines
42with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C07D 405/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
A61K 31/498 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
498Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 241/42
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
36condensed with carbocyclic rings or ring systems
38with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
40Benzopyrazines
42with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C07D 241/44
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
36condensed with carbocyclic rings or ring systems
38with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
40Benzopyrazines
44with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA [US]/[US] (AllExceptUS)
  • NATARAJAN, Amarnath [IN]/[US] (UsOnly)
  • CHEN, Qianyi [CN]/[CN] (UsOnly)
  • BRYANT, Vashti, C. [US]/[US] (UsOnly)
  • RAJULE, Rajkumar [IN]/[US] (UsOnly)
Inventors
  • NATARAJAN, Amarnath
  • CHEN, Qianyi
  • BRYANT, Vashti, C.
  • RAJULE, Rajkumar
Agents
  • DANEK, Shelley
Priority Data
61/415,93422.11.2010US
61/416,00122.11.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) QUINOXALINE COMPOUNDS AND USES THEREOF
(FR) COMPOSÉS DE QUINOXALINE ET LEURS UTILISATIONS
Abstract
(EN)
Disclosed herein are compounds of formula (I) and methods of inhibiting ΙΚΚβ and the NF-κB signaling and mTOR pathways.
(FR)
L'invention concerne des composés de formule (I) et des procédés d'inhibition d'ΙΚΚβ et des voies de signalisation de NF-κB et mTOR.
Also published as
Latest bibliographic data on file with the International Bureau