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1. WO2012071244 - HIGH-THROUGHPUT, SENSITIVE DETECTION OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE

Publication Number WO/2012/071244
Publication Date 31.05.2012
International Application No. PCT/US2011/061207
International Filing Date 17.11.2011
IPC
C12Q 1/54 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
54involving glucose or galactose
G01N 30/72 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
62Detectors specially adapted therefor
72Mass spectrometers
CPC
C12Q 1/32
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
26involving oxidoreductase
32involving dehydrogenase
G01N 2800/22
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
22Haematology
G01N 2800/368
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
36Gynecology or obstetrics
368Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
G01N 33/6893
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6893related to diseases not provided for elsewhere
Applicants
  • DH TECHNOLOGIES DEVELOPMENT PTE. LTD. [SG]/[SG] (AllExceptUS)
  • CASETTA, Bruno [IT]/[IT] (UsOnly)
Inventors
  • CASETTA, Bruno
Agents
  • HERRITT, Danielle, L.
Priority Data
61/416,95724.11.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HIGH-THROUGHPUT, SENSITIVE DETECTION OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE
(FR) DÉTECTION SENSIBLE, À HAUT DÉBIT, DE LA GLUCOSE-6-PHOSPHATE DÉSHYDROGÉNASE
Abstract
(EN)
Provided herein are methods for determining an amount of glucose-6-phosphate dehydrogenase ("G6PDH") in a biological sample. Also provided herein are methods for detecting G6PDH deficiency, as well as diagnosing G6PDH- associated disorders, such as acute hemolytic anemia and pre-eclampsia.
(FR)
La présente invention concerne des procédés de détermination d'une quantité de glucose-6-phosphate déshydrogénase ("G6PDH") dans un échantillon biologique. De plus, l'invention concerne des procédés pour la détection d'une déficience en G6PDH, ainsi que le diagnostic de troubles associés à la G6PDH, tels que l'anémie hémolytique aiguë et la pré-éclampsie.
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