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1. WO2012070025 - PROCESS FOR THE PREPARATION OF AGOMELATINE

Publication Number WO/2012/070025
Publication Date 31.05.2012
International Application No. PCT/IB2011/055314
International Filing Date 26.11.2011
IPC
C07C 213/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
C07C 231/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
02from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
C07C 233/21 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
16having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
17with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
21having the carbon atom of the carboxamide group bound to an acyclic carbon atom of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
CPC
C07C 213/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
C07C 231/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
02from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
C07C 233/21
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
16having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
17with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
21having the carbon atom of the carboxamide group bound to an acyclic carbon atom of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
Applicants
  • CADILA PHARMACEUTICALS LTD [IN]/[IN] (AllExceptUS)
  • KHAMAR, Bakulesh Mafatlal [IN]/[IN] (UsOnly)
  • BHUVA, Chirag Vithalbhai [IN]/[IN] (UsOnly)
  • MUGALE, Balaji Ram [IN]/[IN] (UsOnly)
  • KANANI, Ashok Ratilal [IN]/[IN] (UsOnly)
  • KAGATHARA, Nirav Keshavlal [IN]/[IN] (UsOnly)
  • BAPAT, Uday Rajaram [IN]/[IN] (UsOnly)
  • MODI, Indravadan Ambalal [IN]/[IN] (UsOnly)
Inventors
  • KHAMAR, Bakulesh Mafatlal
  • BHUVA, Chirag Vithalbhai
  • MUGALE, Balaji Ram
  • KANANI, Ashok Ratilal
  • KAGATHARA, Nirav Keshavlal
  • BAPAT, Uday Rajaram
  • MODI, Indravadan Ambalal
Common Representative
  • KHAMAR, Bakulesh Mafatlal
Priority Data
90/MUM/201126.11.2010IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PREPARATION OF AGOMELATINE
(FR) PROCÉDÉ DE PRÉPARATION D'AGOMÉLATINE
Abstract
(EN)
The present invention relates to a process for the manufacture of N-[2-(7-methoxy-1-naphthalenyl) ethyl]acetamide (Agomelatine) with improved yield and reduced level of N- acetyl-N-[2-(7-methoxy-1-naphthalenyl) ethyl]acetamide impurity.
(FR)
La présente invention concerne un procédé pour la fabrication de N-[2-(7-méthoxy-1-naphtalényl)éthyl]acétamide (Agomélatine) présentant un rendement amélioré et un niveau réduit d'impureté N- acétyl-N-[2-(7-méthoxy-1-naphtalényl)éthyl]acétamide.
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