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1. WO2012070015 - INHIBITORS OF THE ACTIVITY OF COMPLEX III OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF FOR TREATING DISEASES

Publication Number WO/2012/070015
Publication Date 31.05.2012
International Application No. PCT/IB2011/055287
International Filing Date 24.11.2011
IPC
C07D 213/81 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
81Amides; Imides
C07D 221/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
221Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/-C07D219/187
02condensed with carbocyclic rings or ring systems
04Ortho- or peri-condensed ring systems
C07D 245/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
245Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
C07D 267/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
267Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
C07D 305/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
305Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
14condensed with carbocyclic rings or ring systems
C07D 313/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
313Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
CPC
A01N 37/44
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
37Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
44containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
A01N 43/24
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
02having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
24with two or more hetero atoms
A01N 43/40
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
34having rings with one nitrogen atom as the only ring hetero atom
40six-membered rings
A01N 43/48
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
48having rings with two nitrogen atoms as the only ring hetero atoms
A01N 43/72
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
72having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
A01N 43/90
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
90having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
Applicants
  • STEMERGIE BIOTECHNOLOGY SA [CH]/[CH] (AllExceptUS)
  • CLEMENT-SCHATLO, Virginie [FR]/[FR] (UsOnly)
  • FESSARD, Thomas [FR]/[CH] (UsOnly)
  • CRIBIU, Riccardo [IT]/[CH] (UsOnly)
Inventors
  • CLEMENT-SCHATLO, Virginie
  • FESSARD, Thomas
  • CRIBIU, Riccardo
Agents
  • KATZAROV SA
Priority Data
01965/1024.11.2010CH
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF THE ACTIVITY OF COMPLEX III OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF FOR TREATING DISEASES
(FR) INHIBITEURS DE L'ACTIVITÉ DU COMPLEXE III DE LA CHAÎNE MITOCHONDRIALE DE TRANSFERT DES ÉLECTRONS ET UTILISATION DE CEUX-CI POUR TRAITER DES MALADIES
Abstract
(EN)
The present invention relates to compounds which are inhibitors of the activity of Complex III of the mitochondrial electron transport chain and pharmaceutical compositions comprising said compounds alone or in combination with other active agents. The present invention further relates to use of the compounds of the invention as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit. More particularly the present invention relates to the use of the compounds of the invention in a method of treating and/or preventing cancers presenting tumor-initiating cells. (Formula I) (I)
(FR)
La présente invention concerne des composés qui sont des inhibiteurs de l'activité du Complexe III de la chaîne mitochondriale de transfert des électrons et les compositions pharmaceutiques comprenant lesdits composés seuls ou en combinaison avec d'autres agents actifs. La présente invention concerne encore l'utilisation des composés de l'invention en tant que médicaments ou en tant que produits agrochimiques où leurs propriétés en tant qu'inhibiteurs de la respiration mitochondriale sont bénéfiques. Plus particulièrement, la présente invention concerne l'utilisation des composés de l'invention dans un procédé de traitement et/ou de prévention des cancers présentant des cellules initiant la tumeur. (Formule I) (I)
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