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1. WO2012069654 - DESIGNED REPEAT PROTEINS BINDING TO SERUM ALBUMIN

Publication Number WO/2012/069654
Publication Date 31.05.2012
International Application No. PCT/EP2011/071083
International Filing Date 25.11.2011
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
B01D 15/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
C07K 14/001
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
001by chemical synthesis
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Applicants
  • MOLECULAR PARTNERS AG [CH]/[CH] (AllExceptUS)
  • STEINER, Daniel [CH]/[CH] (UsOnly)
  • BINZ, Hans Kaspar [CH]/[CH] (UsOnly)
  • GULOTTI-GEORGIEVA, Maya [CH]/[CH] (UsOnly)
  • MERZ, Frieder W. [DE]/[CH] (UsOnly)
  • PHILLIPS, Douglas [GB]/[CH] (UsOnly)
  • SONDEREGGER, Ivo [CH]/[CH] (UsOnly)
Inventors
  • STEINER, Daniel
  • BINZ, Hans Kaspar
  • GULOTTI-GEORGIEVA, Maya
  • MERZ, Frieder W.
  • PHILLIPS, Douglas
  • SONDEREGGER, Ivo
Agents
  • BECKER, Konrad
Priority Data
10192711.926.11.2010EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DESIGNED REPEAT PROTEINS BINDING TO SERUM ALBUMIN
(FR) PROTÉINES DE RÉPÉTITION CONÇUES SE LIANT À L'ALBUMINE SÉRIQUE
Abstract
(EN)
New designed repeat proteins with binding specificity for serum albumin are described, as well as nucleic acids encoding such serum albumin binding proteins, pharmaceutical compositions comprising such proteins, the use of such proteins to modify the pharmacokinetics of therapeutic relevant polypeptides and the use of such proteins in the treatment of diseases. The repeat proteins of the invention have a substantially increased half-life in plasma compared to proteins not binding serum albumin.
(FR)
La présente invention a pour objet de nouvelles protéines de répétition conçues présentant une spécificité de liaison pour l'albumine sérique, ainsi que des acides nucléiques codant de telles protéines se liant à l'albumine sérique, des compositions pharmaceutiques comprenant de telles protéines, l'utilisation de telles protéines pour modifier la pharmacocinétique de polypeptides thérapeutiquement pertinents et l'utilisation de telles protéines dans le traitement de maladies. Les protéines de répétition selon l'invention ont une demi-vie sensiblement accrue dans le plasma comparé aux protéines ne se liant pas à l'albumine sérique.
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