Processing

Please wait...

PATENTSCOPE will be unavailable a few hours for maintenance reason on Saturday 31.10.2020 at 7:00 AM CET
Settings

Settings

Goto Application

1. WO2012069434 - METHOD FOR PRODUCING N-HETEROCYCLIC OPTICALLY ACTIVE ALCOHOLS

Publication Number WO/2012/069434
Publication Date 31.05.2012
International Application No. PCT/EP2011/070607
International Filing Date 22.11.2011
IPC
C12P 7/22 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
02containing a hydroxy group
22aromatic
C12N 9/04 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02Oxidoreductases (1.), e.g. luciferase
04acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
CPC
C07D 211/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
20with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms
22by oxygen atoms
C07D 213/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
28Radicals substituted by singly-bound oxygen or sulfur atoms
30Oxygen atoms
C12N 9/0006
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
0004Oxidoreductases (1.)
0006acting on CH-OH groups as donors (1.1)
C12P 17/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
C12P 17/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
12containing a six-membered hetero ring
C12P 41/002
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
002by oxidation/reduction reactions
Applicants
  • BASF SE [DE]/[DE] (AllExceptUS)
  • SCHNEIDER, Nina [DE]/[DE] (UsOnly)
  • BONNEKESSEL, Melanie [DE]/[DE] (UsOnly)
  • BREUER, Michael [DE]/[DE] (UsOnly)
  • DÄUWEL, Jürgen [DE]/[DE] (UsOnly)
  • DITRICH, Klaus [DE]/[DE] (UsOnly)
  • KARL, Ulrich [DE]/[DE] (UsOnly)
  • STÄB, Tobias [DE]/[DE] (UsOnly)
Inventors
  • SCHNEIDER, Nina
  • BONNEKESSEL, Melanie
  • BREUER, Michael
  • DÄUWEL, Jürgen
  • DITRICH, Klaus
  • KARL, Ulrich
  • STÄB, Tobias
Common Representative
  • BASF SE
Priority Data
10192418.124.11.2010EP
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) VERFAHREN ZUR HERSTELLUNG N-HETEROZYKLISCHER OPTISCH AKTIVER ALKOHOLE
(EN) METHOD FOR PRODUCING N-HETEROCYCLIC OPTICALLY ACTIVE ALCOHOLS
(FR) PROCÉDÉ DE FABRICATION D'ALCOOLS OPTIQUEMENT ACTIFS N-HÉTÉROCYCLIQUES
Abstract
(DE)
Verfahren zur Herstellung von N-heterozyklischen optisch aktiven Alkoholen der Formel (I), worin R1 für Alkylgruppen stehen, die wiederum ein- oder mehrfach substituiert sein können, durch Alkyl, Halogen, SH.SR3,OH, OR3, NO2, CN, CO, COOR3, NR3R4 oder NR3R3R5+X-, wobei R3, R4 und R5 unabhängig voneinander für H oder einen Niedrigalkyl- oder Niedrigalkoxy-Rest stehen und X- für ein Gegenion steht, R2 für N-haltige Heteroarylgruppen stehen, die wiederum ein- oder mehrfach substituiert sein können, durch Alkyl, Halogen, SH.SR3,OH, OR3, NO2, CN, CO, COOR3, NR3R4 oder NR3R3R5+X-, wobei R3, R4 und R5 unabhängig voneinander für H oder einen Niedrigalkyl- oder Niedrigalkoxy-Rest stehen und X- für ein Gegenion steht durch Reduktion des entsprechenden Ketons, wobei die Reduktion mit einer Dehydrogenase mit der Polypeptidsequenz SEQ ID NO:2 oder NO:4, oder mit einer Polypeptidsequenz, bei der bis zu 25% der Aminosäurereste gegenüber SEQ ID NO:2 oder NO:4 durch Deletion; Insertion, Substitution oder einer Kombination davon verändert sind, durchgeführt wird.
(EN)
Method for producing N-heterocyclic optically active alcohols of the formula (I), where R1 represents alkyl groups which in turn can be monosubstituted or polysubstituted by alkyl, halogen, SH.SR3, OH, OR3, NO2, CN, CO, COOR3, NR3R4 or NR3R3R5+X-, where R3, R4 and R5 independently of one another are H or a low-alkyl or low-alkoxy radical and X- is a counterion, R2 is N-containing heteroaryl groups which in turn can be monosubstituted or polysubstituted by alkyl, halogen, SH.SR3, OH, OR3, NO2, CN, CO, COOR3, NR3R4 or NR3R3R5+X-, where R3, R4 and R5 independently of one another are H or a low-alkyl or low-alkoxy radical and X- is a counterion, by reduction of the corresponding ketone, wherein the reduction is carried out using a dehydrogenase having the polypeptide sequence SEQ ID NO: 2 or NO: 4, or having a polypeptide sequence in which up to 25% of the amino acid radicals are modified in comparison with SEQ ID NO: 2 or NO: 4 by deletion, insertion, substitution or a combination thereof.
(FR)
L'invention concerne un procédé de fabrication d'alcools optiquement actifs N-hétérocycliques de la formule (I), dans laquelle R1 représente des groupes alkyle, lesquels, de nouveau, peuvent être substitués une ou plusieurs fois par alkyle, halogène, SH.SR3, OH, OR3, NO2, CN, CO, COOR3, NR3R4 ou NR3R3R5+X-, où R3, R4 et R5 représentent indépendamment les uns des autres H ou un reste alkyle inférieur ou alcoxy inférieur et X- représente un contre-ion, R2 représente des groupes hétéroaryle à teneur en N, lesquels, de nouveau, peuvent être substitués une ou plusieurs fois par alkyle, halogène, SH.SR3, OH, OR3, NO2, CN, CO, COOR3, NR3R4 ou NR3R3R5+X-, où R3, R4 et R5 représentent indépendamment les uns des autres H ou un reste alkyle inférieur ou alcoxy inférieur et X- représente un contre-ion, par réduction de la cétone correspondante, la réduction étant réalisée avec une déshydrogénase ayant la séquence polypeptidique SEQ ID NO:2 ou NO:4, ou ayant une séquence polypeptidique dans laquelle jusqu'à 25 % des restes acide aminé sont modifiés par rapport à SEQ ID NO:2 ou NO:4 par délétion, insertion, substitution ou une combinaison de celles-ci.
Also published as
Latest bibliographic data on file with the International Bureau