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1. WO2012069004 - SYNTHESIS AND APPLICATION OF INTERMEDIATE OF TAPENTADOL

Publication Number WO/2012/069004
Publication Date 31.05.2012
International Application No. PCT/CN2011/082915
International Filing Date 25.11.2011
IPC
C07D 263/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02not condensed with other rings
08having one double bond between ring members or between a ring member and a non-ring member
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18Oxygen atoms
20attached in position 2
22with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
C07C 59/64 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40Unsaturated compounds
58containing ether groups, groups, groups, or groups
64containing six-membered aromatic rings
C07C 51/09 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
51Preparation of carboxylic acids or their salts, halides, or anhydrides
09from carboxylic acid esters or lactones
C07C 57/72 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
57Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
64Acyl halides
72containing six-membered aromatic rings
C07C 51/60 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
51Preparation of carboxylic acids or their salts, halides, or anhydrides
58Preparation of carboxylic acid halides
60by conversion of carboxylic acids or their anhydrides into halides with the same carboxylic acid part
C07C 235/34 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
32the carbon skeleton containing six-membered aromatic rings
34having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
CPC
C07B 2200/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
07Optical isomers
C07C 213/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
C07C 213/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
02by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
C07C 231/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
02from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
C07C 51/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
51Preparation of carboxylic acids or their salts, halides or anhydrides
58Preparation of carboxylic acid halides
60by conversion of carboxylic acids or their anhydrides ; or esters, lactones, salts; into halides with the same carboxylic acid part
C07D 263/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02not condensed with other rings
08having one double bond between ring members or between a ring member and a non-ring member
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18Oxygen atoms
20attached in position 2
22with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
Applicants
  • 中国医学科学院药物研究所 INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES [CN]/[CN] (AllExceptUS)
  • 冯文化 FENG, Wenhua [CN]/[CN] (UsOnly)
  • 马慧 MA, Hui [CN]/[CN] (UsOnly)
Inventors
  • 冯文化 FENG, Wenhua
  • 马慧 MA, Hui
Agents
  • 北京三高永信知识产权代理有限责任公司 BEIJING SAN GAO YONG XIN INTELLECTUAL PROPERTY AGENCY CO., LTD.
Priority Data
201010567805.626.11.2010CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) SYNTHESIS AND APPLICATION OF INTERMEDIATE OF TAPENTADOL
(FR) SYNTHÈSE ET APPLICATION D'INTERMÉDIAIRE DE TAPENTADOL
(ZH) 他喷他多的中间体的合成与应用
Abstract
(EN)
Disclosed are a preparation method for a key intermediate of tapentadol: (1R, 2R)-1-ethyl-2-methylbenzene ethane compound, and a method for applying the key intermediate in the preparation of tapentadol and a derivative thereof.
(FR)
La présente invention concerne un procédé de préparation pour un intermédiaire clé du tapentadol : composé de (1R,2R)-1-éthyl-2-méthylbenzène-éthane, et un procédé pour appliquer l'intermédiaire clé dans la préparation de tapentadol et un dérivé de celui-ci.
(ZH)
本发明公开了一种他喷他多的关键中间体:(1R,2R)-1-乙基-2-甲基苯乙烷类化合物的制备方法,以及应用这个关键中间体制备他喷他多及衍生物的方法。
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