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1. WO2012068560 - 4-QUINOLINEMETHANOLS AS ANTI-MALARIAL AGENTS

Publication Number WO/2012/068560
Publication Date 24.05.2012
International Application No. PCT/US2011/061550
International Filing Date 18.11.2011
IPC
A61K 31/47 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
CPC
A61P 31/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
06for tuberculosis
A61P 33/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
06Antimalarials
C07D 215/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
12with substituted hydrocarbon radicals attached to ring carbon atoms
14Radicals substituted by oxygen atoms
C07D 401/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Applicants
  • JENRIN DISCOVERY [US]/[US] (AllExceptUS)
  • MCELROY, John [US]/[US] (UsOnly)
  • CHORVAT, Robert [US]/[US] (UsOnly)
  • NUGIEL, David [US]/[US] (UsOnly)
Inventors
  • MCELROY, John
  • CHORVAT, Robert
  • NUGIEL, David
Agents
  • VANCE, David
Priority Data
61/415,07118.11.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 4-QUINOLINEMETHANOLS AS ANTI-MALARIAL AGENTS
(FR) 4-QINOLINEMÉTHANOLS UTILISÉS COMME AGENTS ANTIPALUDIQUES
Abstract
(EN)
The present invention relates to substituted 4-quinoline methanol derivatives that are ring-opened and substituted piperidine analogs of mefloquine, pharmaceutical compositions containing an effective amount of said analogs and methods of using the same for the manufacture of a medicament for treating of malaria, tuberculosis, and other infectious diseases.
(FR)
La présente invention concerne des 4-qinolineméthanols et des compositions pharmaceutiques de ceux-ci. Elle concerne également des méthodes d'utilisation de ceux-ci pour le traitement du paludisme, de la tuberculose et d'autres maladies infectieuses.
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