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1. WO2012068477 - METHODS AND COMPOSITIONS FOR INHIBITING ANGIOGENESIS AND TUMOR GROWTH

Publication Number WO/2012/068477
Publication Date 24.05.2012
International Application No. PCT/US2011/061430
International Filing Date 18.11.2011
IPC
A61K 38/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
A61K 38/1709
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
1703from vertebrates
1709from mammals
A61K 38/19
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • VASGENE THERAPEUTICS, INC. [US]/[US] (AllExceptUS)
  • LIU, Ren [CN]/[US] (UsOnly)
  • KRASNOPEROV, Valery [RU]/[US] (UsOnly)
  • GILL, Parkash [US]/[US] (UsOnly)
Inventors
  • LIU, Ren
  • KRASNOPEROV, Valery
  • GILL, Parkash
Agents
  • HALSTEAD, David, P.
Priority Data
61/415,78819.11.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR INHIBITING ANGIOGENESIS AND TUMOR GROWTH
(FR) MÉTHODES ET COMPOSITIONS DESTINÉES À L'INHIBITION DE L'ANGIOGENÈSE ET DE LA CROISSANCE TUMORALE
Abstract
(EN)
In certain embodiments, this present invention provides compositions, and methods for inhibiting Eph/Ephrin pathway activity in combination with D114/Notch pathway inhibition. In other embodiments, the present invention provides methods and compositions for inhibiting angiogenesis, for inhibiting tumor growth, for treating cancer or for treating angiogenesis-associated diseases.
(FR)
Dans certains modes de réalisation, cette présente invention concerne des compositions et des méthodes destinées à l'inhibition de l'activité de la voie Eph/Ephrin en combinaison avec l'inhibition de la voie D114/Notch. Dans d'autres modes de réalisation, la présente invention a pour objet des méthodes et des compositions destinées à l'inhibition de l'angiogenèse, à l'inhibition de la croissance tumorale, au traitement du cancer ou au traitement de maladies associées à une angiogenèse.
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