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1. WO2012068470 - IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE

Publication Number WO/2012/068470
Publication Date 24.05.2012
International Application No. PCT/US2011/061412
International Filing Date 18.11.2011
IPC
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07H 21/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
CPC
A61K 31/7115
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7115Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
A61K 31/7125
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7125Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
Applicants
  • IDERA PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • KANDIMALLA, Ekambar, R. [US]/[US] (UsOnly)
  • WANG, Daqing [CA]/[US] (UsOnly)
  • NOWAK, Ireneusz [PL]/[US] (UsOnly)
  • AGRAWAL, Sudhir [US]/[US] (UsOnly)
Inventors
  • KANDIMALLA, Ekambar, R.
  • WANG, Daqing
  • NOWAK, Ireneusz
  • AGRAWAL, Sudhir
Agents
  • ZUCCHERO, Joseph C.
Priority Data
61/415,49419.11.2010US
61/511,70926.07.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE
(FR) COMPOSÉS OLIGONUCLÉOTIDIQUES IMMUNO-RÉGULATEURS (IRO) CAPABLES DE MODULER LA RÉPONSE IMMUNITAIRE FONDÉE SUR LES RÉCEPTEURS DE TYPE TOLL (TLR)
Abstract
(EN)
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
(FR)
La présente invention concerne des oligonucléotides immuno-régulateurs (IRO) inédits utilisables en tant qu'antagonistes des TLR, ainsi que leurs méthodes d'utilisation. Ces IRO comportent des séquences uniques qui inhibent ou suppriment la signalisation à médiation par les TLR en réponse à un ligand des TLR ou à un agoniste des TLR. Ces méthodes peuvent être utilisées dans le cadre de la prévention et du traitement du cancer, d'une maladie auto-immune, d'une inflammation des voies aériennes, de troubles inflammatoires, d'une maladie infectieuse, d'affections cutanées, d'allergie, d'asthme ou d'une maladie provoquée par un agent pathogène.
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