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1. WO2012068187 - POLY(AMIDE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES

Publication Number WO/2012/068187
Publication Date 24.05.2012
International Application No. PCT/US2011/060893
International Filing Date 16.11.2011
IPC
A61K 31/7088 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
CPC
A61K 47/549
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
549Sugars, nucleosides, nucleotides or nucleic acids
C08G 69/10
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
69Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
02Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
08derived from amino-carboxylic acids
10Alpha-amino-carboxylic acids
C08G 73/028
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
73Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
02Polyamines
028Polyamidoamines
C08L 79/02
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
79Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
02Polyamines
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US] (AllExceptUS)
  • BARRETT, Stephanie, E. [CA]/[US] (NZ, US)
  • BUSUEK, Marina [US]/[US] (NZ, US)
  • COLLETTI, Steven, L. [US]/[US] (NZ, US)
  • GARBACCIO, Robert, M. [US]/[US] (NZ, US)
  • GUIDRY, Erin, N. [US]/[US] (NZ, US)
  • KOWTONIUK, Robert, A. [US]/[US] (NZ, US)
  • LIAO, Jing [CN]/[US] (NZ, US)
  • PARISH, Craig, A. [US]/[US] (NZ, US)
  • PARMAR, Rubina, G. [US]/[US] (NZ, US)
  • PEI, Tao [US]/[US] (NZ, US)
  • SCHLOSSER, Kevin, M. [US]/[US] (NZ, US)
  • TELLERS, David, M. [US]/[US] (NZ, US)
  • TOBIAS, Sandra, C. [US]/[US] (NZ, US)
  • TRUONG, Quang, T. [US]/[US] (NZ, US)
  • WALDMAN, Jacob, H. [US]/[US] (NZ, US)
  • WANG, Weimin [US]/[US] (NZ, US)
  • WILLIAMS, J. Michael [US]/[US] (NZ, US)
Inventors
  • BARRETT, Stephanie, E.
  • BUSUEK, Marina
  • COLLETTI, Steven, L.
  • GARBACCIO, Robert, M.
  • GUIDRY, Erin, N.
  • KOWTONIUK, Robert, A.
  • LIAO, Jing
  • PARISH, Craig, A.
  • PARMAR, Rubina, G.
  • PEI, Tao
  • SCHLOSSER, Kevin, M.
  • TELLERS, David, M.
  • TOBIAS, Sandra, C.
  • TRUONG, Quang, T.
  • WALDMAN, Jacob, H.
  • WANG, Weimin
  • WILLIAMS, J. Michael
Common Representative
  • MERCK SHARP & DOHME CORP.
Priority Data
61/415,54619.11.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLY(AMIDE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES
(FR) POLYMÈRES POLY(AMIDE) DESTINÉS À L'ADMINISTRATION D'OLIGONUCLÉOTIDES
Abstract
(EN)
The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
(FR)
La présente invention concerne des polymères poly(amide), des polyconjugués, des compositions et des procédés destinés à l'administration d'oligonucléotides à des fins thérapeutiques.
Also published as
Latest bibliographic data on file with the International Bureau