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1. WO2012067427 - PHARMACEUTICAL COMPOSITION CONTAINING LK8 PROTEIN AS AN ACTIVE INGREDIENT FOR PREVENTING OR TREATING DIABETIC RETINOPATHY OR AGE-RELATED MACULAR DEGENERATION

Publication Number WO/2012/067427
Publication Date 24.05.2012
International Application No. PCT/KR2011/008761
International Filing Date 16.11.2011
IPC
A61K 38/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61P 27/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 3/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 27/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
CPC
A61K 38/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61P 27/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
Applicants
  • 재단법인 목암생명공학연구소 MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE [KR]/[KR] (AllExceptUS)
  • 안진형 AHN, Jin-Hyung [KR]/[KR] (UsOnly)
  • 임양미 LIM, Yang Mi [KR]/[KR] (UsOnly)
  • 김정훈 KIM, Jeong Hun [KR]/[KR] (UsOnly)
  • 유현경 YU, Hyun-Kyung [KR]/[KR] (UsOnly)
  • 최하나 CHOI, Hana [KR]/[KR] (UsOnly)
  • 윤엽 YOON, Yeup [KR]/[KR] (UsOnly)
  • 황유경 HWANG, Yu Kyeong [KR]/[KR] (UsOnly)
Inventors
  • 안진형 AHN, Jin-Hyung
  • 임양미 LIM, Yang Mi
  • 김정훈 KIM, Jeong Hun
  • 유현경 YU, Hyun-Kyung
  • 최하나 CHOI, Hana
  • 윤엽 YOON, Yeup
  • 황유경 HWANG, Yu Kyeong
Agents
  • 제일특허법인 FIRSTLAW P.C.
Priority Data
61/414,23916.11.2010US
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION CONTAINING LK8 PROTEIN AS AN ACTIVE INGREDIENT FOR PREVENTING OR TREATING DIABETIC RETINOPATHY OR AGE-RELATED MACULAR DEGENERATION
(FR) COMPOSITION PHARMACEUTIQUE CONTENANT LA PROTÉINE LK8 EN TANT QUE PRINCIPE ACTIF, DANS LA PRÉVENTION OU LE TRAITEMENT DE LA RÉTINOPATHIE DIABÉTIQUE OU DE LA DÉGÉNÉRESCENCE MACULAIRE LIÉE À L'ÂGE
(KO) LK8 단백질을 유효성분으로 포함하는 당뇨망막병증 또는 노인성 황반변성의 예방 또는 치료용 약학 조성물
Abstract
(EN)
The present invention relates to a pharmaceutical composition containing, as an active ingredient, LK8 protein having an amino acid sequence depicted in sequence identification number 1, for preventing or treating diabetic retinopathy or age-related macular degeneration. The LK8 protein has an effect of inhibiting a bond between fibronectin and vascular endothelial cells, and therefore, can be valuably used as a composition for preventing or treating diabetic retinopathy or age-related macular degeneration.
(FR)
La présente invention concerne une composition pharmaceutique contenant, en tant que principe actif, une protéine LK8 possédant une séquence d'acides aminés représentée dans l'identification de séquence numéro 1, destinée à la prévention ou au traitement de la rétinopathie diabétique ou de la dégénérescence maculaire liée à l'âge. La protéine LK8 possède un effet inhibiteur sur une liaison entre la fibronectine et des cellules endothéliales vasculaires, et peut donc être utile en tant que composition dans la prévention ou le traitement de la rétinopathie diabétique ou de la dégénérescence maculaire liée à l'âge.
(KO)
본 발명은 서열번호 1로 표시되는 아미노산 서열을 갖는 LK8 단백질을 유효성분으로 포함하는, 당뇨망막병증 또는 노인성 황반변성의 예방 또는 치료용 약학 조성물에 관한 것으로서, LK8 단백질은 피브로넥틴과 혈관내피세포와의 결합을 억제하는 효능이 있어 당뇨망막병증 또는 노인성 황반변성의 예방 또는 치료용 조성물로서 유용하게 사용될 수 있다.
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