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1. WO2012066994 - PHARMACEUTICAL FORMULATION HAVING NEUROPROTECTIVE ACTIVITY

Publication Number WO/2012/066994
Publication Date 24.05.2012
International Application No. PCT/JP2011/075802
International Filing Date 09.11.2011
IPC
A61K 31/58 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
58containing heterocyclic rings, e.g. aldosterone, danazol, stanozolol, pancuronium, digitogenin
A61K 31/255 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
255of sulfoxy acids or sulfur analogues thereof
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 27/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 31/136
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
135having aromatic rings ; , e.g. ketamine, nortriptyline
136having the amino group directly attached to the aromatic ring, e.g. benzeneamine
A61K 31/185
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
A61K 31/58
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
58containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
Applicants
  • 国立大学法人九州大学 KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION [JP]/[JP] (AllExceptUS)
  • 石橋 達朗 ISHIBASHI Tatsurou [JP]/[JP] (UsOnly)
  • 久冨 智朗 HISATOMI Toshio [JP]/[JP] (UsOnly)
  • 納富 昭司 NOUTOMI Syouji [JP]/[JP] (UsOnly)
  • 江内田 寛 ENAIDA Hiroshi [JP]/[JP] (UsOnly)
  • 鍵本 忠尚 KAGIMOTO Tadahisa [JP]/[JP] (UsOnly)
Inventors
  • 石橋 達朗 ISHIBASHI Tatsurou
  • 久冨 智朗 HISATOMI Toshio
  • 納富 昭司 NOUTOMI Syouji
  • 江内田 寛 ENAIDA Hiroshi
  • 鍵本 忠尚 KAGIMOTO Tadahisa
Agents
  • 廣瀬 隆行 HIROSE Takayuki
Priority Data
2010-25542215.11.2010JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) PHARMACEUTICAL FORMULATION HAVING NEUROPROTECTIVE ACTIVITY
(FR) FORMULATION PHARMACEUTIQUE AYANT UNE ACTIVITÉ NEUROPROTECTRICE
(JA) 神経保護作用を持つ薬剤配合
Abstract
(EN)
[Problem] The purpose of the present invention is to provide a neuroprotective agent which is capable of effectively protecting intraocular cells including optic nerves and is effective as a composition for ophthalmic membrane staining in cases where removal of an ophthalmic membrane is carried out. [Solution] The purpose is achieved by a neuroprotective agent which contains, as active ingredients: Brilliant Blue G, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof; and triamcinolone acetonide, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof. This neuroprotective agent has ophthalmic membrane staining effect due to BBG and exhibits extremely high neuroprotective activity due to synergetic effect of Brilliant Blue G and triamcinolone acetonide.
(FR)
L'objectif de la présente invention est d'apporter un agent neuroprotecteur qui est apte à protéger efficacement les cellules intraoculaires, comprenant les nerfs optiques, et est efficace en tant que composition pour le marquage de la membrane ophtalmique dans des cas où l'extraction d'une membrane ophtalmique est réalisée. L'objectif est atteint par un agent neuroprotecteur qui contient, en tant que principes actifs : le Bleu Brillant G, un sel pharmaceutiquement acceptable de celui-ci ou un solvate pharmaceutiquement acceptable de celui-ci ; et l'acétonide de triamcinolone, un sel pharmaceutiquement acceptable de celui-ci ou un solvate pharmaceutiquement acceptable de celui-ci. Cet agent neuroprotecteur possède un effet de marquage de membrane ophtalmique à cause de BBG et présente une activité neuroprotectrice extrêmement élevée en raison de l'effet synergique du Bleu Brillant G et de l'acétonide de triamcinolone.
(JA)
【課題】 本発明は,視神経を含む眼内細胞を効果的に保護でき,更に眼膜除去を行う際の眼膜染色用組成物として有効である神経保護剤を提供することを目的とする。 【解決手段】 上記の課題は,ブリリアントブルーG,その薬学的に許容される塩,又はその薬学的に許容される溶媒和物と,トリアムシノロンアセトニド,その薬学的に許容される塩,又はその薬学的に許容される溶媒和物と,を有効成分として含む神経保護剤により解決される。この神経保護剤は,BBGに由来する眼膜染色作用を有するとともに,ブリリアントブルーGとトリアムシノロンアセトニドとによる相乗効果により極めて高い神経保護作用を発揮する。
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