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1. WO2012066486 - COMPOUND ETHYL 8-OXO-9-[3-(1H-BENZIMIDAZOL-2-YLOXY)PHENYL]-4,5,6,7,8,9-HEXAHYDRO-2H-PYRROLO[3,4-B]QUINOLINE-3-CARBOXYLATE, SALT, CRYSTALLINE FORM, COCRYSTAL, FORMULATION, PROCESSES FOR PREPARATION, APPLICATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NEW USE PARTICULARLY AS INHIBITOR OF AURORA KINASES

Publication Number WO/2012/066486
Publication Date 24.05.2012
International Application No. PCT/IB2011/055115
International Filing Date 16.11.2011
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/4745 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4738ortho- or peri-condensed with heterocyclic ring systems
4745condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • SANOFI [FR]/[FR] (AllExceptUS)
  • AROKIASSAMY, Nathalie [FR]/[FR] (UsOnly)
  • BILLOT, Pascal [FR]/[FR] (UsOnly)
  • CARRY, Jean-Christophe [FR]/[FR] (UsOnly)
  • CLAVIERES, Patrick [FR]/[FR] (UsOnly)
  • CLERC, François [FR]/[FR] (UsOnly)
  • CROCQ - STUERGA, Véronique [FR]/[FR] (UsOnly)
  • LACHAUD, Sylvette [FR]/[FR] (UsOnly)
  • LIENARD, Philippe [FR]/[FR] (UsOnly)
  • MENEGOTTO, Jérôme [FR]/[FR] (UsOnly)
  • SCHIO, Laurent [FR]/[FR] (UsOnly)
Inventors
  • AROKIASSAMY, Nathalie
  • BILLOT, Pascal
  • CARRY, Jean-Christophe
  • CLAVIERES, Patrick
  • CLERC, François
  • CROCQ - STUERGA, Véronique
  • LACHAUD, Sylvette
  • LIENARD, Philippe
  • MENEGOTTO, Jérôme
  • SCHIO, Laurent
Agents
  • BOURGOUIN-MULLER, Alessandra
Priority Data
105945617.11.2010FR
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUND ETHYL 8-OXO-9-[3-(1H-BENZIMIDAZOL-2-YLOXY)PHENYL]-4,5,6,7,8,9-HEXAHYDRO-2H-PYRROLO[3,4-B]QUINOLINE-3-CARBOXYLATE, SALT, CRYSTALLINE FORM, COCRYSTAL, FORMULATION, PROCESSES FOR PREPARATION, APPLICATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NEW USE PARTICULARLY AS INHIBITOR OF AURORA KINASES
(FR) COMPOSÉ D'ÉTHYLE 8-OXO-9-[3-(1H-BENZIMIDAZOL-2-YLOXY)PHÉNYL]-4,5,6,7,8,9-HEXAHYDRO-2H-PYRROLO[3,4-B]QUINOLINE-3-CARBOXYLATE, SEL, FORME CRISTALLINE, CO-CRISTAL, PRÉPARATION, PROCÉDÉS DE PRÉPARATION, APPLICATION EN TANT QUE MÉDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION, EN PARTICULIER EN TANT QU'INHIBITEUR DES KINASES AURORA
Abstract
(EN)
The invention relates more particularly to a new salt, cocrystal and formulations of ethyl 8-oxo-9-[3-(1H-benzimidazol-2-yloxy)phenyl]-4,5,6,7,8,9-hexahydro-2H- pyrrolo[3,4-b]quinoline-3-carboxylate of formula (F) to preparations thereof and to the use thereof therapeutically, particularly as selective inhibitors of Aurora A and B kinases, and for their use as anti-cancer agents.
(FR)
L'invention concerne en particulier un nouveau sel, un co-cristal et des préparations d'éthyle 8-oxo-9-[3-(1H-benzimidazol-2-yloxy)phényl]-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]quinoline-3-carboxylate de formule (F), des compositions associées ainsi que leur utilisation sur le plan thérapeutique, en particulier en tant qu'inhibiteurs sélectifs des kinases Aurora A et B, ainsi que leur utilisation en tant qu'agents anticancéreux.
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