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1. WO2012066481 - NEW ETHIOLOGICAL AGENT

Publication Number WO/2012/066481
Publication Date 24.05.2012
International Application No. PCT/IB2011/055103
International Filing Date 15.11.2011
IPC
C12N 7/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
C12N 15/33 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
C12N 15/41 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
41Picornaviridae, e.g. rhinovirus, coxsackie viruses, echoviruses, enteroviruses
C07K 14/085 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
085Picornaviridae, e.g. coxsackie virus, echovirus, enterovirus
C07K 16/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
A61K 39/125 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
125Picornaviridae, e.g. calicivirus
CPC
A61K 2039/5252
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5252inactivated (killed)
A61K 2039/552
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
55characterised by the host/recipient, e.g. newborn with maternal antibodies
552Veterinary vaccine
A61K 2039/55566
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55566Emulsions, e.g. Freund's adjuvant, MF59
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
C12N 2770/16034
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
16011Caliciviridae
16034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
Applicants
  • PHARMAQ AS [NO]/[NO] (AllExceptUS)
  • NILSEN, Pål [NO]/[NO] (UsOnly)
  • FRØYSTAD-SAUGEN, Marianne [NO]/[NO] (UsOnly)
  • LINDMO, Karine [NO]/[NO] (UsOnly)
  • MIKALSEN, Aase Beathe [NO]/[NO] (UsOnly)
  • EVENSEN, Øystein [NO]/[NO] (UsOnly)
  • RODE, Marit [NO]/[NO] (UsOnly)
Inventors
  • NILSEN, Pål
  • FRØYSTAD-SAUGEN, Marianne
  • LINDMO, Karine
  • MIKALSEN, Aase Beathe
  • EVENSEN, Øystein
  • RODE, Marit
Agents
  • PLOUGMANN & VINGTOFT A/S
Priority Data
2010160415.11.2010NO
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NEW ETHIOLOGICAL AGENT
(FR) NOUVEL AGENT ÉTIOLOGIQUE
Abstract
(EN)
The present invention relates to an isolated non-enveloped, positive stranded RNA virus. The invention further relates to an isolated nucleic acid sequence transcribed from the viral genome and to isolated or recombinant amino acid sequences corresponding to proteins encoded by a nucleic acid sequence within an open reading frame in the viral genome. The invention further provides antibodies, nucleic acid sequences, immunogenic compositions and methods of manufacturing such, methods of detecting the virus, and diagnostic kits. Finally, the invention also provides a virus of the invention for use in medicine and use of a virus of the invention in the manufacture of an immunological composition.
(FR)
Cette invention concerne un virus à ARN à brin positif isolé, non enveloppé. Elle concerne, en outre, une séquence d'acide nucléique isolée transcrite à partir du génome viral et des séquences d'acides aminés recombinantes correspondant aux protéines codées par une séquence d'acide nucléique dans un cadre de lecture ouvert du génome viral. Cette invention concerne également des anticorps, des séquences d'acides nucléiques, des compositions immunogènes et des procédés pour les préparer, des procédés pour détecter le virus, et des kits diagnostiques. Pour finir, un virus selon l'invention destiné à être utilisé en médecine et l'utilisation d'un virus selon l'invention dans la fabrication d'une composition immunologique sont également décrits.
Also published as
Latest bibliographic data on file with the International Bureau