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1. WO2012066254 - PHARMACEUTICAL COMPOSITION COMPRISING KREBS CYCLE PRECURSOR SALT, IN PARTICULAR CITRATE SALT, AND USE THEREOF AS A MEDICAMENT

Publication Number WO/2012/066254
Publication Date 24.05.2012
International Application No. PCT/FR2011/052691
International Filing Date 18.11.2011
IPC
A61K 9/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
28Dragees; Coated pills or tablets
A61K 9/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
A61K 31/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
CPC
A61K 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
A61K 31/194
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
194having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
A61K 9/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
A61K 9/2866
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
2833Organic macromolecular compounds
286Polysaccharides, e.g. gums; Cyclodextrin
2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 13/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
04for urolithiasis
Applicants
  • ADVICENNE [FR]/[FR] (AllExceptUS)
  • ROUSSEL-MAUPETIT, Caroline [FR]/[FR] (UsOnly)
  • GRANIER, Luc-André [FR]/[FR] (UsOnly)
  • GUITTET, Catherine [FR]/[FR] (UsOnly)
Inventors
  • ROUSSEL-MAUPETIT, Caroline
  • GRANIER, Luc-André
  • GUITTET, Catherine
Agents
  • SALOU, Clarisse
Priority Data
105946818.11.2010FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION COMPRISING KREBS CYCLE PRECURSOR SALT, IN PARTICULAR CITRATE SALT, AND USE THEREOF AS A MEDICAMENT
(FR) COMPOSITION PHARMACEUTIQUE COMPRENANT DU SEL PRECURSEUR DU CYCLE DE KREBS, EN PARTICULIER DU SEL DE CITRATE, ET SON UTILISATION COMME MEDICAMENT
Abstract
(EN)
A solid oral pharmaceutical composition in the form of a tablet consisting of a core comprising a Krebs cycle precursor salt as active ingredient, and of a coating comprising a coating agent, said composition comprising from 40% to 80% by weight of this precursor salt on the basis of the total weight of the composition, said composition being able to release this salt in vitro, both in purified water at pH 7 and in a solution buffered at pH 1.3, with a dissolution device in accordance with the European Pharmacopoeia, at a rate of from 2 to 15% in 15 minutes, from 15 to 25% in 30 minutes, and from 30 to 50% in one hour. The use thereof as a medicament, in particular in the treatment and/or prevention of urinary lithiasis occurring at a physiological pH and/or during urinary acidosis and/or during hypocitraturia and/or during hypercalciuria and/or during hyperoxaluria.
(FR)
Composition pharmaceutique solide à usage oral sous forme de comprimé constitué d'un cœur comprenant un sel précurseur du cycle de Krebs en tant que principe actif, et d'un enrobage comprenant un agent d'enrobage, ladite composition comprenant de 40 % à 80 % en poids de ce sel précurseur sur la base du poids total de la composition, ladite composition étant apte à libérer ce sel in vitro, aussi bien dans l'eau purifiée à pH 7 que dans une solution tamponnée à pH 1,3, avec un appareil de dissolution conforme à la Pharmacopée Européenne, à un taux de 2 à 15 % en 15 minutes, de 15 à 25 % en 30 minutes, et de 30 à 50 % en une heure. Son utilisation comme médicament, en particulier dans le traitement et/ou la prévention des lithiases urina ires se manifestant à un pH physiologique et/ou lors d'acidose urinaire et/ou lors d'hypocitraturie et/ou lors d'hypercalciurie et/ou lors d'hyperoxalurie.
Latest bibliographic data on file with the International Bureau