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1. WO2012065286 - COMPOSITION OF DNA VACCINE FOR PREVENTING AND TREATING HEPATITIS B

Publication Number WO/2012/065286
Publication Date 24.05.2012
International Application No. PCT/CN2010/077979
International Filing Date 19.11.2010
IPC
A61K 39/29 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
29Hepatitis virus
A61K 39/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
CPC
A61K 2039/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
53DNA (RNA) vaccination
A61K 2039/55527
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55522Cytokines; Lymphokines; Interferons
55527Interleukins
A61K 2039/55561
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55561CpG containing adjuvants; Oligonucleotide containing adjuvants
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/29
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
29Hepatitis virus
A61K 39/292
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
29Hepatitis virus
292Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
Applicants
  • 北京凯因科技股份有限公司 BEIJING KAWIN TECHNOLOGY SHARE-HOLDING CO., LTD. [CN]/[CN] (AllExceptUS)
  • 北京凯因生物技术有限公司 BEIJING KAWIN BIO-TECH CO., LTD. [CN]/[CN] (AllExceptUS)
  • 刘勇 LIU, Yong [CN]/[CN] (UsOnly)
  • 李鼎峰 LI, Dingfeng [CN]/[CN] (UsOnly)
  • 张春丽 ZHANG, Chunli [CN]/[CN] (UsOnly)
  • 侯建华 HOU, Jianhua [CN]/[CN] (UsOnly)
Inventors
  • 刘勇 LIU, Yong
  • 李鼎峰 LI, Dingfeng
  • 张春丽 ZHANG, Chunli
  • 侯建华 HOU, Jianhua
Agents
  • 北京市柳沈律师事务所 LIU, SHEN & ASSOCIATES
Priority Data
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) COMPOSITION OF DNA VACCINE FOR PREVENTING AND TREATING HEPATITIS B
(FR) COMPOSITION DE VACCIN À ADN POUR LA PRÉVENTION OU LE TRAITEMENT DE L'HÉPATITE B
(ZH) 一种用于预防和治疗乙型肝炎的DNA疫苗组合物
Abstract
(EN)
The present invention provides a composition of DNA vaccine for treating Hepatitis B, wherein the composition comprises a recombinant plasmid for expressing hepatitis B surface antigen, a recombinant plasmid for expressing hepatitis B core antigen, and a recombinant plasmid as adjuvant. Preferably, the recombinant plasmid for expressing hepatitis B surface antigen comprises a gene encoding the middle protein S2S of envelope protein of hepatitis B virus or small protein S of envelope protein of hepatitis B virus. The present invention further provides uses of the composition of DNA vaccine for preventing and/or treating the infection of hepatitis B virus.
(FR)
L'invention concerne une composition de vaccin à ADN pour le traitement de l'hépatite B, qui comprend: un plasmide recombinant pouvant exprimer un antigène de surface de l'hépatite B; un plasmide recombinant pouvant exprimer l'antigène capsidique de l'hépatite B; et un plasmide recombinant utilisé comme adjuvant. De préférence, le plasmide recombinant pouvant exprimer un antigène de surface de l'hépatite B comprend un gène qui code pour la protéine moyenne S2S de la protéine d'enveloppe du virus de l'hépatite B, ou pour la petite protéine S de la protéine d'enveloppe du virus de l'hépatite B. L'invention concerne en outre des utilisations de la composition de vaccin à ADN destinée à la prévention et/ou au traitement de l'infection par le virus de l'hépatite B.
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