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1. WO2012064914 - PEPTIDOMIMETIC INHIBITORS OF PSMA

Publication Number WO/2012/064914
Publication Date 18.05.2012
International Application No. PCT/US2011/060088
International Filing Date 10.11.2011
IPC
C07F 9/09 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P-C bonds
08Esters of oxyacids of phosphorus
09Esters of phosphoric acids
C07F 9/11 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P-C bonds
08Esters of oxyacids of phosphorus
09Esters of phosphoric acids
11with hydroxyalkyl compounds without further substituents on alkyl
A61K 31/66 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/664
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
664Amides of phosphorus acids
A61K 51/0489
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
0489Phosphates or phosphonates, e.g. bone-seeking phosphonates;
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07F 13/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
13Compounds containing elements of Groups 7 or 17 of the Periodic System
005Compounds without a metal-carbon linkage
C07F 9/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P—C bonds
22Amides of acids of phosphorus
24Esteramides
C07F 9/2408
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P—C bonds
22Amides of acids of phosphorus
24Esteramides
2404the ester moiety containing a substituent or a structure which is considered as characteristic
2408of hydroxyalkyl compounds
Applicants
  • WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION [US]/[US] (AllExceptUS)
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US] (AllExceptUS)
  • BERKMAN, Clifford, E. [US]/[US] (UsOnly)
  • VANBROCKLIN, Henry, F. [US]/[US] (UsOnly)
Inventors
  • BERKMAN, Clifford, E.
  • VANBROCKLIN, Henry, F.
Agents
  • WHITHAM, Michael, E.
Priority Data
61/412,91712.11.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PEPTIDOMIMETIC INHIBITORS OF PSMA
(FR) INHIBITEURS PEPTIDOMIMÉTIQUES DE PSMA
Abstract
(EN)
Compounds of the formulae, (I), wherein each variable is as defined herein are provided which are useful in (i) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable carrier, excipient, and/or diluent; (3) methods for inhibiting or treating prostrate cancer; and (4) methods for blocking or destabilizing neovasculature of a tumor.
(FR)
L'invention concerne des composés de formule (I), où chaque variable est telle que définie présentement, qui sont utiles dans (i) des méthodes de diagnostic pour la détection et/ou l'identification de cellules présentant le PSMA; (2) des compositions comprenant un composé de l'invention conjointement à un vecteur, excipient et/ou diluant pharmaceutiquement acceptable; (3) des procédés d'inhibition ou des méthodes de traitement du cancer de la prostate; et (4) des procédés de blocage ou de déstabilisation de la néovasculature d'une tumeur.
Also published as
Latest bibliographic data on file with the International Bureau