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1. WO2012064674 - MATERIALS AND METHODS FOR IMMUNOASSAY OF PTERINS

Publication Number WO/2012/064674
Publication Date 18.05.2012
International Application No. PCT/US2011/059652
International Filing Date 07.11.2011
IPC
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
C07D 475/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
475Heterocyclic compounds containing pteridine ring systems
02with an oxygen atom directly attached in position 4
04with a nitrogen atom directly attached in position 2
CPC
C07D 475/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
475Heterocyclic compounds containing pteridine ring systems
02with an oxygen atom directly attached in position 4
04with a nitrogen atom directly attached in position 2
C07D 487/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
C09B 15/00
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
15Acridine dyes
G01N 33/5308
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
5308for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
Applicants
  • ABBOTT LABORATORIES [US]/[US] (AllExceptUS)
  • ADAMCZYK, Maciej [US]/[US] (UsOnly)
  • BRASHEAR, R., Jeffrey [US]/[US] (UsOnly)
  • HSU, Stephen, C. [US]/[US] (UsOnly)
  • MATTINGLY, Phillip, G. [US]/[US] (UsOnly)
Inventors
  • ADAMCZYK, Maciej
  • BRASHEAR, R., Jeffrey
  • HSU, Stephen, C.
  • MATTINGLY, Phillip, G.
Agents
  • LARCHER, Carol
Priority Data
12/942,78109.11.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MATERIALS AND METHODS FOR IMMUNOASSAY OF PTERINS
(FR) MATÉRIELS ET MÉTHODES POUR UN IMMUNOESSAI PERMETTANT D'ANALYSER LES PTÉRINES
Abstract
(EN)
Methods of assaying for (i) a pterin by immunoassay employing a pterin as capture agent, (ii) neopterin by chemiluminescent microparticle immunoassay (CMIA) employing an anti-neopterin antibody (Ab) as capture agent, (iii) neopterin by an immunoassay (IA) employing an acridinium (Acr)-labeled anti-neopterin Ab as conjugate, and (iv) neopterin by an IA employing Acr-labeled neopterin as tracer; an Acr-labeled anti-neopterin Ab; a conjugate/complex comprising anti-neopterin Ab and a carrier scaffold; a conjugated pterin; a conjugate comprising an Acr-labeled pterin and a carrier scaffold; an immunogen comprising neopterin and a carrier protein; a conjugate comprising such an immunogen and an Acr compound; an immunogen comprising a carrier protein and a neopterin hapten; a conjugate comprising such an immunogen and an Acr compound; a kit for assaying a pterin comprising a pterin as a capture agent and instructions for IA; and a kit for assaying neopterin comprising an anti-neopterin Ab as a capture agent and instructions for CMIA, neopterin comprising an Acr-labeled anti-neopterin Ab as a conjugate and instructions for IA, or Acr-labeled neopterin as a tracer and instructions for IA.
(FR)
L'invention concerne des procédés permettant d'analyser (i) une ptérine au moyen d'un immunoessai utilisant une ptérine comme agent de capture, (ii) une néoptérine au moyen d'un immunoessai par microparticules chimioluminescentes (CMIA) utilisant un anticorps (Ab) anti-néoptérine comme agent de capture, (iii) une néoptérine au moyen d'un immunoessai (IE) utilisant un Ab anti-néoptérine marqué à l'acridinium (Acr) comme conjugué et (iv) une néoptérine au moyen d'un IE utilisant une néoptérine à marquage Acr comme traceur ; un Ab anti-néoptérine à marquage Acr ; un conjugué/complexe comprenant un Ab anti-néoptérine et une structure de support de base ; une ptérine conjuguée ; un conjugué comprenant une ptérine à marquage Acr et une structure de support de base ; un immunogène comprenant une néoptérine et une protéine de support ; un conjugué comprenant un tel immunogène et un composé d'Acr ; un immunogène comprenant une protéine de support et un haptène de néoptérine ; un conjugué comprenant un tel immunogène et un composé d'Acr ; un kit d'analyse de ptérine comprenant une ptérine en tant qu'agent de capture et des instructions pour l'IE ; et un kit d'analyse de néoptérine comprenant un Ab anti-néoptérine en tant qu'agent de capture et des instructions pour le CMIA, une néoptérine comprenant un Ab anti-néoptérine à marquage Acr en tant que conjugué et des instructions pour l'IE ou une néoptérine à marquage Acr en tant que traceur et des instructions pour l'IE.
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