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1. WO2012064603 - OXAZOLIDINONES AS MODULATORS OF MGLUR5

Publication Number WO/2012/064603
Publication Date 18.05.2012
International Application No. PCT/US2011/059339
International Filing Date 04.11.2011
IPC
C07D 263/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02not condensed with other rings
08having one double bond between ring members or between a ring member and a non-ring member
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18Oxygen atoms
C07D 413/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 413/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
C07D 413/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
C07D 263/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02not condensed with other rings
08having one double bond between ring members or between a ring member and a non-ring member
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18Oxygen atoms
C07D 413/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 413/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
C07D 413/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
Applicants
  • BRISTOL-MYERS SQUIBB COMPANY [US]/[US] (AllExceptUS)
  • DEGNAN, Andrew P. [US]/[US] (UsOnly)
  • HUANG, Hong [US]/[US] (UsOnly)
  • SNYDER, Lawrence B. [US]/[US] (UsOnly)
  • YANG, Fukang [CN]/[US] (UsOnly)
  • GILLMAN, Kevin W. [US]/[US] (UsOnly)
  • PARKER, Michael F. [US]/[US] (UsOnly)
Inventors
  • DEGNAN, Andrew P.
  • HUANG, Hong
  • SNYDER, Lawrence B.
  • YANG, Fukang
  • GILLMAN, Kevin W.
  • PARKER, Michael F.
Agents
  • EPPERSON, James
Priority Data
61/412,54111.11.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) OXAZOLIDINONES AS MODULATORS OF MGLUR5
(FR) OXAZOLIDINONES EN TANT QUE MODULATEURS DE MGLUR5
Abstract
(EN)
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial agonists for the mGluR5 receptor and may be useful for the treatment of various disorders of the central nervous system.
(FR)
L'invention concerne généralement des composés de formule I, comprenant leurs sels, ainsi que des compositions et des procédés d'utilisation des composés. Les composés sont des ligands, des agonistes et des agonistes partiels pour le récepteur mGluR5 et peuvent être utiles pour le traitement de divers troubles du système nerveux central.
Also published as
Latest bibliographic data on file with the International Bureau