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1. WO2012062213 - CASPOFUNGIN ANALOG AND APPLICATIONS THEREOF

Publication Number WO/2012/062213
Publication Date 18.05.2012
International Application No. PCT/CN2011/082022
International Filing Date 10.11.2011
IPC
A61K 38/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
C07K 7/56 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50Cyclic peptides containing at least one abnormal peptide link
54with at least one abnormal peptide link in the ring
56the cyclisation not occurring through 2,4-diamino-butanoic acid
C07K 1/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
06using protecting groups or activating agents
A61P 31/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides ; , e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
A61P 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
C07K 7/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50Cyclic peptides containing at least one abnormal peptide link
54with at least one abnormal peptide link in the ring
56the cyclisation not occurring through 2,4-diamino-butanoic acid
Applicants
  • 上海天伟生物制药有限公司 SHANGHAI TECHWELL BIOPHARMACEUTICAL CO., LTD [CN]/[CN] (AllExceptUS)
  • 何兵明 HE, Bingming [CN]/[CN] (UsOnly)
  • 李明 LI, Ming [CN]/[CN] (UsOnly)
  • 唐志军 TANG, Zhijun [CN]/[CN] (UsOnly)
  • 季晓铭 JI, Xiaoming [CN]/[CN] (UsOnly)
Inventors
  • 何兵明 HE, Bingming
  • 李明 LI, Ming
  • 唐志军 TANG, Zhijun
  • 季晓铭 JI, Xiaoming
Agents
  • 上海专利商标事务所有限公司 SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC
Priority Data
201010538954.X10.11.2010CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CASPOFUNGIN ANALOG AND APPLICATIONS THEREOF
(FR) ANALOGUE DE LA CASPONFUNGINE ET SES APPLICATIONS
(ZH) 一种卡泊芬净类似物及其用途
Abstract
(EN)
Disclosed are a caspofungin analog and applications thereof. Said caspofungin analog is a compound having a structure as indicated in Formula (4), or pharmaceutically acceptable salts thereof. R1 can be chosen from hydroxy, benzyloxy, phenoxy, substituted phenoxy, or substituted benzyloxy. R2, R3, R4, and R5 can be chosen from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, benzyloxy phenyl, substituted benzyloxy phenyl, nitryl, fluorine, chlorine, bromine, or iodine. Also disclosed are a preparation method for and applications of said compound.
(FR)
L'invention concerne un analogue de la casponfungine et ses applications, l'analogue étant un composé dont la structure est de formule 4 ou son sel pharmaceutiquement acceptable, R1 étant sélectionné dans hydroxy, benzyloxy, phénoxy, phénoxy substitué ou benzyloxy substitué; R2, R3, R4 et R5 étant sélectionnés dans hydrogène, alkyle en C1-C6, alcoxy en C1-C6, hydroxyle, benzyloxy-phényle, benzyl phényle substitué, nitro, fluor, chlore, brome ou iode. L'invention concerne en outre un procédé de préparation de ce composé et ses applications.
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