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1. WO2012061954 - PREPARATIVE METHOD AND USE OF ZINGIBERENSIS SAPONIN EXTRACTED FROM DIOSCOREA ZINGIBERENSIS WITH ANTITUMOR ACTIVITY

Publication Number WO/2012/061954
Publication Date 18.05.2012
International Application No. PCT/CN2010/001801
International Filing Date 10.11.2010
IPC
A61K 31/7048 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61K 36/8945 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
88Liliopsida (monocotyledons)
894Dioscoreaceae (Yam family)
8945Dioscorea, e.g. yam, Chinese yam or water yam
C07J 21/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
21Normal steroids containing carbon, hydrogen, halogen, or oxygen, having an oxygen-containing hetero ring spiro-condensed with the cyclopentahydrophenanthrene skeleton
C07J 75/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
75Processes for the preparation of steroids, in general
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
CPC
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
A61K 36/8945
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
88Liliopsida (monocotyledons)
894Dioscoreaceae (Yam family)
8945Dioscorea, e.g. yam, Chinese yam or water yam
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
C07J 71/0005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
71Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
0005Oxygen-containing hetero ring
Applicants
  • 北京大学 PEKING UNIVERSITY [CN]/[CN] (AllExceptUS)
  • 黄文 HUANG, Wen [CN]/[CN] (UsOnly)
  • 吴晓华 WU, Xiaohua [CN]/[CN] (UsOnly)
  • 倪晋仁 NI, Jinren [CN]/[CN] (UsOnly)
Inventors
  • 黄文 HUANG, Wen
  • 吴晓华 WU, Xiaohua
  • 倪晋仁 NI, Jinren
Agents
  • 中科专利商标代理有限责任公司 CHINA SCIENCE PATENT & TRADEMARK AGENT LTD
Priority Data
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PREPARATIVE METHOD AND USE OF ZINGIBERENSIS SAPONIN EXTRACTED FROM DIOSCOREA ZINGIBERENSIS WITH ANTITUMOR ACTIVITY
(FR) PROCÉDÉ DE PRÉPARATION ET D'UTILISATION DE SAPONINE DE ZINGIBERENSIS EXTRAITE DE DIOSCOREA ZINGIBERENSIS À ACTIVITÉ ANTITUMORALE
(ZH) 具有抗癌活性的黄姜盾叶新苷的制备方法和用途
Abstract
(EN)
The preparative method of zingiberensis saponin with structure as followed (I) extracted from Dioscorea zingiberensis comprises steps as followed: extracting the tuber of Dioscorea zingiberensis C. H. Wright. as raw material using one or more solvents selected from water and C1-4 fatty alcohol, reduced pressure condensing, freeze- drying to obtain total steroidal saponins from Dioscorea zingiberensis, then separating and purifying through normal phase silica gel column chromatograph, gel chromatograph and recrystallization, receiving zingiberensis saponin extracted from Dioscorea zingiberensis. The use of zingiberensis saponin with structure as followed extracted from Dioscorea zingiberensis in the preparation of medicaments for treating or preventing cancers. The cancers are selected from colon cancer, lung cancer, mammary cancer, cervical cancer and ovary cancer.
(FR)
L'invention concerne un procédé de préparation de saponine de zingiberensis dont la structure (I) est indiquée dans la description et qui est extraite de Dioscorea zingiberensis. Le procédé comprend les étapes suivantes qui consistent : à extraire la tubercule de Dioscorea zingiberensis C. H. Wright en tant que matière première au moyen d'un ou plusieurs solvants sélectionnés parmi eau et alcool gras C1-4, à condenser sous pression réduite, à lyophiliser pour obtenir des saponines stéroïdiennes totales à partir de Dioscorea zingiberensis; puis à séparer et purifier par chromatographie sur colonne à gel de silice en phase normale, chromatographie sur gel et recristallisation; et à obtenir la saponine de zingiberensis extraite de Dioscorea zingiberensis. L'invention concerne l'utilisation de la saponine de zingiberensis dont la structure est indiquée dans la description extraite de Dioscorea zingiberensis dans la préparation de médicaments pour traiter ou prévenir des cancers. Parmi les cancers concernés, on peut citer le cancer du côlon, le cancer du poumon, le cancer du sein, le cancer du col de l'utérus et le cancer des ovaires.
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