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1. WO2012061790 - COMBINATION THERAPY FOR PROSTATE CANCER USING BOTANICAL COMPOSITIONS AND BICALUTAMIDE

Publication Number WO/2012/061790
Publication Date 10.05.2012
International Application No. PCT/US2011/059471
International Filing Date 04.11.2011
IPC
A01N 65/00 2009.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
65Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
CPC
A61K 31/277
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
275Nitriles; Isonitriles
277having a ring, e.g. verapamil
A61K 36/074
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
06Fungi, e.g. yeasts
07Basidiomycota, e.g. Cryptococcus
074Ganoderma
A61K 36/537
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
537Salvia (sage)
A61K 36/539
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
539Scutellaria (skullcap)
A61K 38/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
24Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
A61K 9/2086
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2072characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
Applicants
  • GENYOUS BIOMED INTERNATIONAL [US]/[US] (AllExceptUS)
  • DAO, James [US]/[US] (UsOnly)
  • DAO, Jeffrey [US]/[US]
  • GAO, Allen, Chuan [US]/[US] (UsOnly)
  • GERWICK, William [US]/[US] (UsOnly)
  • GERWICK, Lena [US]/[US] (UsOnly)
  • JORDAN, MaryAnn [US]/[US] (UsOnly)
  • MIKOVITS, Judy [US]/[US] (UsOnly)
  • OKOUNEVA, Tatiana [US]/[US] (UsOnly)
  • OROUDJEV, Emin [US]/[US] (UsOnly)
Inventors
  • DAO, James
  • DAO, Jeffrey
  • GAO, Allen, Chuan
  • GERWICK, William
  • GERWICK, Lena
  • JORDAN, MaryAnn
  • MIKOVITS, Judy
  • OKOUNEVA, Tatiana
  • OROUDJEV, Emin
Agents
  • BASU, Shantanu
Priority Data
61/410,32704.11.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATION THERAPY FOR PROSTATE CANCER USING BOTANICAL COMPOSITIONS AND BICALUTAMIDE
(FR) MULTITHÉRAPIE POUR LE CANCER DE LA PROSTATE UTILISANT DES COMPOSITIONS VÉGÉTALES ET DU BICALUTAMIDE
Abstract
(EN)
Botanical compositions comprising non-alcoholic organic extracts of Ganoderma lucidum, Salvia miltiorrhiza, and Scutellaria barbata for use in conjunction with bicalutamide therapy fpr cancer therapy, are provided. Methods for treatment or therapy of prostate cancer in a human is provided, the method comprising: administering an effective amount of a botanical composition that is effective for reducing androgen receptor protein expression; and administering concurrently an effective amount of a compound having anti-androgen activity, wherein the concurrent administration of the compound and the botanical composition achieves a therapeutic effect that is more effective than either agent alone.
(FR)
Cette invention concerne des compositions végétales comprenant des extraits organiques non alcooliques de Ganoderma lucidum, Salvia miltiorrhiza et Scutellaria barbata à utiliser conjointement avec le bicalutamide dans un traitement anticancéreux. L'invention concerne également des méthodes de traitement du cancer de la prostate chez l'homme, lesdites méthodes consistant à : administrer une quantité efficace d'une composition végétale qui réduit effectivement l'expression des récepteurs androgéniques; et à administrer conjointement une quantité efficace d'un composé présentant une activité anti-androgène, l'administration conjointe du composé et de la composition végétale permettant d'obtenir un effet thérapeutique plus efficace que l'administration séparée de chacun des composants.
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