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1. WO2012061789 - TETRAMERIC ALPHA-SYNUCLEIN AND USE THEREOF

Publication Number WO/2012/061789
Publication Date 10.05.2012
International Application No. PCT/US2011/059470
International Filing Date 04.11.2011
IPC
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
A61K 45/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
G01N 2800/2821
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
28Neurological disorders
2814Dementia; Cognitive disorders
2821Alzheimer
G01N 2800/2835
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
28Neurological disorders
2835Movement disorders, e.g. Parkinson, Huntington, Tourette
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
G01N 33/6893
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6893related to diseases not provided for elsewhere
Applicants
  • BRANDEIS UNIVERSITY [US]/[US] (AllExceptUS)
  • THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US]/[US] (AllExceptUS)
  • RINGE, Dagmar [US]/[US] (UsOnly)
  • PETSKO, Gregory, A. [US]/[US] (UsOnly)
  • SELKOE, Dennis, J. [US]/[US] (UsOnly)
  • BARTELS, Tim [DE]/[US] (UsOnly)
Inventors
  • RINGE, Dagmar
  • PETSKO, Gregory, A.
  • SELKOE, Dennis, J.
  • BARTELS, Tim
Agents
  • NIHAN, Danielle, M.
Priority Data
61/410,86005.11.2010US
61/410,86105.11.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TETRAMERIC ALPHA-SYNUCLEIN AND USE THEREOF
(FR) ALPHA-SYNUCLÉINE TÉTRAMÉRIQUE ET SON UTILISATION
Abstract
(EN)
Disclosed herein are methods and related compositions for identifying compounds that stabilize natively folded tetrameric α-synuclein. These methods and compositions are useful for the treatment and diagnosis of α-synuclein -associated diseases and disorders.
(FR)
L'invention concerne des procédés et des compositions correspondantes destinés à identifier des composés qui stabilisent une α-synucléine tétramérique naturellement repliée. Ces procédés et ces compositions sont utiles dans le traitement et le diagnostic de maladies et des troubles associés à l'α-synucléine.
Also published as
Latest bibliographic data on file with the International Bureau