Processing

Please wait...

PATENTSCOPE will be unavailable a few hours for maintenance reason on Saturday 31.10.2020 at 7:00 AM CET
Settings

Settings

Goto Application

1. WO2012061759 - FOLATE RECEPTOR ALPHA AS A DIAGNOSTIC AND PROGNOSTIC MARKER FOR FOLATE RECEPTOR ALPHA-EXPRESSING CANCERS

Publication Number WO/2012/061759
Publication Date 10.05.2012
International Application No. PCT/US2011/059411
International Filing Date 04.11.2011
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
G01N 33/574 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
G01N 33/82 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
82involving vitamins
CPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 15/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
08for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
Applicants
  • MORPHOTEK INC. [US]/[US] (AllExceptUS)
  • O'SHANNESSY, Daniel, J. [AU]/[US] (UsOnly)
  • GRASSO, Luigi [US]/[US] (UsOnly)
  • WAN, Shanhong [US]/[US] (UsOnly)
  • CHAO, Qimin [US]/[US] (UsOnly)
  • SOMERS, Elizabeth, Brooke [US]/[US] (UsOnly)
Inventors
  • O'SHANNESSY, Daniel, J.
  • GRASSO, Luigi
  • WAN, Shanhong
  • CHAO, Qimin
  • SOMERS, Elizabeth, Brooke
Agents
  • ZACHARAKIS, Maria, Laccotripe
Priority Data
61/410,49705.11.2010US
61/508,44415.07.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FOLATE RECEPTOR ALPHA AS A DIAGNOSTIC AND PROGNOSTIC MARKER FOR FOLATE RECEPTOR ALPHA-EXPRESSING CANCERS
(FR) RÉCEPTEUR ALPHA DE FOLATE À TITRE DE MARQUEUR DIAGNOSTIQUE ET PRONOSTIQUE DES CANCERS EXPRIMANT UN RÉCEPTEUR ALPHA DE FOLATE
Abstract
(EN)
The present invention provides methods and kits for assessing whether a subject is afflicted with an FRα-expressing cancer, methods and kits for predicting the progression of ovarian cancer in a subject afflicted with an FRα-expressing cancer, methods and kits for assessing the level of risk that a subject will develop an FRα- expressing cancer, and methods of stratifying a subject with an FRα-expressing cancer into cancer therapy groups. The methods involve determining the level of folate receptor alpha (FRα) which is not bound to a cell in a sample derived from the subject and comparing this level with the level of FRα in a control sample.
(FR)
Cette invention concerne des méthodes et des kits permettant d'évaluer si un sujet est atteint d'un cancer exprimant FRα, des méthodes et des kits permettant de prédire l'évolution d'un cancer de l'ovaire chez une patiente atteinte d'un cancer exprimant FRα, des méthodes et des kits permettant d'évaluer le niveau de risque d'un sujet à développer un cancer exprimant FRα, et des méthodes pour stratifier un sujet ayant un cancer exprimant FRα dans des groupes de thérapie anticancéreuse. Les méthodes selon l'invention impliquent la détermination du taux de récepteurs alpha de folate (FRα) qui n'est pas lié à une cellule dans un échantillon dérivé du sujet et la comparaison de ce taux au taux de FRα dans un échantillon témoin.
Latest bibliographic data on file with the International Bureau