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1. (WO2012061590) CYTOTOXIC AGENTS COMPRISING NEW ANSAMITOCIN DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/061590 International Application No.: PCT/US2011/059131
Publication Date: 10.05.2012 International Filing Date: 03.11.2011
IPC:
A61K 39/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
IMMUNOGEN, INC. [US/US]; 830 Winter Street Waltham, MA 02451, US (AllExceptUS)
CHARI, Ravi, V. J. [US/US]; US (UsOnly)
WIDDISON, Wayne, C. [US/US]; US (UsOnly)
WILHELM, Sharon, D. [US/US]; US (UsOnly)
Inventors:
CHARI, Ravi, V. J.; US
WIDDISON, Wayne, C.; US
WILHELM, Sharon, D.; US
Agent:
DAVIS, Steven, G.; McCarter & English, LLP 265 Franklin Street Boston, MA 02110, US
Priority Data:
61/409,83103.11.2010US
Title (EN) CYTOTOXIC AGENTS COMPRISING NEW ANSAMITOCIN DERIVATIVES
(FR) AGENTS CYTOTOXIQUES COMPRENANT DE NOUVEAUX DÉRIVÉS D'ANSAMITOCINE
Abstract:
(EN) New ansamitocin derivatives bearing a linking group are disclosed. Also disclosed are methods for the synthesis of these new ansamitocin derivatives and methods for their linkage to cell-binding agents. The ansamitocin derivative- cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.
(FR) La présente invention concerne de nouveaux dérivés d'ansamitocine comportant un groupe de liaison. La présente invention concerne en outre des procédés pour la synthèse de ces nouveaux dérivés d'ansamitocine et des procédés pour leur liaison à des agents de liaison cellulaire. Les conjugués dérivé d'ansamitocine-agent de liaison cellulaire sont utiles en tant qu'agents thérapeutiques, qui sont délivrés spécifiquement à des cellules cibles et sont cytotoxiques. Ces conjugués présentent une efficacité thérapeutique grandement améliorée dans des modèles de tumeur chez l'animal par rapport aux agents précédemment décrits.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2635301CN103269712CA2816681JP2013542958US20130323268EA201390642
MX2013005046BR112013010853AU2011323316CN106349254