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1. WO2012061552 - NOVEL INHIBITORS OF HEPATITIS C VIRUS

Publication Number WO/2012/061552
Publication Date 10.05.2012
International Application No. PCT/US2011/059061
International Filing Date 03.11.2011
IPC
C07D 403/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14containing three or more hetero rings
A61K 31/4025 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025not condensed and containing further heterocyclic rings, e.g. cromakalim
A61K 31/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
CPC
A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
14containing three or more hetero rings
Applicants
  • THERAVANCE, INC. [US]/[US] (AllExceptUS)
  • MCKINNELL, Robert Murray [GB]/[US] (UsOnly)
  • LONG, Daniel D. [GB]/[US] (UsOnly)
  • VAN ORDEN, Lori Jean [US]/[US] (UsOnly)
  • JIANG, Lan [CN]/[US] (UsOnly)
  • LOO, Mandy [US]/[US] (UsOnly)
  • SAITO, Daisuke Roland [US]/[US] (UsOnly)
  • ZIPFEL, Sheila [US]/[US] (UsOnly)
  • STANGELAND, Eric L. [US]/[US] (UsOnly)
  • LEPACK, Kassandra [CA]/[US] (UsOnly)
  • OGAWA, Gavin [US]/[US] (UsOnly)
  • HUANG, Xiaojun [CA]/[US] (UsOnly)
  • ZHANG, Weijiang [US]/[US] (UsOnly)
Inventors
  • MCKINNELL, Robert Murray
  • LONG, Daniel D.
  • VAN ORDEN, Lori Jean
  • JIANG, Lan
  • LOO, Mandy
  • SAITO, Daisuke Roland
  • ZIPFEL, Sheila
  • STANGELAND, Eric L.
  • LEPACK, Kassandra
  • OGAWA, Gavin
  • HUANG, Xiaojun
  • ZHANG, Weijiang
Agents
  • HAGENAH, Jeffrey, A.
Priority Data
61/410,26704.11.2010US
61/444,04617.02.2011US
61/492,26701.06.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL INHIBITORS OF HEPATITIS C VIRUS
(FR) NOUVEAUX INHIBITEURS DU VIRUS DE L'HÉPATITE C
Abstract
(EN)
The invention provides compounds of formula (I) wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.
(FR)
La présente invention concerne des composés de formule (I) où les variables sont définies dans la description, ou leurs sels de qualité pharmaceutique, qui sont des inhibiteurs de la réplication du virus de l'hépatite C. La présente invention concerne également des compositions pharmaceutiques incluant de tels composés, des méthodes d'utilisation de tels composés dans le traitement des infections par le virus de l'hépatite C, et des procédés et intermédiaires permettant la synthèse de tels composés.
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