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1. WO2012061203 - ENHANCEMENT OF PATHOGEN-SPECIFIC MEMORY TH17 CELL RESPONSES

Publication Number WO/2012/061203
Publication Date 10.05.2012
International Application No. PCT/US2011/058124
International Filing Date 27.10.2011
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 39/145 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
A61P 37/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 31/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
CPC
A61K 2039/55572
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
A61K 2039/6056
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6031Proteins
6056Antibodies
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
A61K 39/385
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
385Haptens or antigens, bound to carriers
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
Applicants
  • BAYLOR RESEARCH INSTITUTE [US]/[US] (AllExceptUS)
  • OH, SangKon [KR]/[US] (UsOnly)
  • BANCHEREAU, Jacques F. [FR]/[US] (UsOnly)
  • ZURAWSKI, Gerard [AU]/[US] (UsOnly)
  • UENO, Hideki [JP]/[US] (UsOnly)
  • NI, Ling [CN]/[US] (UsOnly)
Inventors
  • OH, SangKon
  • BANCHEREAU, Jacques F.
  • ZURAWSKI, Gerard
  • UENO, Hideki
  • NI, Ling
Agents
  • FLORES, Edwin S.
Priority Data
13/282,11226.10.2011US
61/409,50702.11.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ENHANCEMENT OF PATHOGEN-SPECIFIC MEMORY TH17 CELL RESPONSES
(FR) AUGMENTATION DES RÉPONSES DES CELLULES MÉMOIRES TH17 SPÉCIFIQUES D'UN AGENT PATHOGÈNE
Abstract
(EN)
Compositions and methods for enhancing Th1/Th17 cell responses and decreasing Th2 cell responses are disclosed herein. In various embodiments the present invention describes activation of human dendritic cells and enhancement of antigen-specific T cell responses in a Dectin-1-expressing human dendritic cells comprising an anti-Dectin-1-specific antibody or fragment thereof fused with one or more antigens. TLR2 ligands may also be included to enhance the activation and for enhancement of T-cell responses. Further, the invention also includes methods based on the compositions described herein for the treatment of pathogenic infections.
(FR)
Cette invention concerne des compositions et des procédés pour augmenter les réponses des cellules Th1/Th17 et diminuer les réponses des cellules Th2. Dans divers modes de réalisation, la présente invention décrit l'activation des cellules dendritiques humaines et l'augmentation des réponses des cellules T spécifiques d'un antigène, dans des cellules dendritiques humaines exprimant la dectine-1, comprenant un anticorps spécifique anti-dectine-1 ou un fragment de celui-ci fusionné avec un ou plusieurs antigènes. Des ligands TLR2 peuvent également être inclus pour augmenter l'activation et les réponses des cellules T. En outre, l'invention a également trait à des procédés fondés sur les compositions décrites ici pour le traitement d'infections pathogènes.
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