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1. WO2012061015 - L-CITRULLINE SUPPLEMENTATION DURING ARGININE DEPLETION THERAPY WITH ARGINASE

Publication Number WO/2012/061015
Publication Date 10.05.2012
International Application No. PCT/US2011/056831
International Filing Date 19.10.2011
IPC
A61K 31/198 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A61K 31/195 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61K 38/50
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
50acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • SCOTT & WHITE HEALTHCARE [US]/[US] (AllExceptUS)
  • FRANKEL, Arthur, E. [US]/[US] (UsOnly)
  • MAULDIN, Jeremy, P. [US]/[US] (UsOnly)
  • WOO, Jung, Hee [US]/[US] (UsOnly)
Inventors
  • FRANKEL, Arthur, E.
  • MAULDIN, Jeremy, P.
  • WOO, Jung, Hee
Agents
  • SISTRUNK, Melissa, L.
Priority Data
61/409,79503.11.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) L-CITRULLINE SUPPLEMENTATION DURING ARGININE DEPLETION THERAPY WITH ARGINASE
(FR) SUPPLÉMENTATION EN L-CITRULLINE AU COURS D'UNE THÉRAPIE DE DÉPLÉTION D'ARGININE PAR L'ARGINASE
Abstract
(EN)
The present invention concerns methods and compositions for reducing toxicity of an anticancer agent that involve citrulline or an analog thereof. Nonlimiting examples of anticancer agents include arginine depletion agents.
(FR)
La présente invention concerne des procédés et des compositions pour la réduction de la toxicité d'un agent anticancéreux qui met en jeu la citrulline ou un analogue de celle-ci. Des exemples non limitants d'agents anticancéreux comprennent des agents de déplétion de l'arginine.
Latest bibliographic data on file with the International Bureau