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1. (WO2012059936) PHARMACEUTICAL COMPOSITIONS FOR COLLOIDAL DRUG DELIVERY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/059936 International Application No.: PCT/IN2011/000730
Publication Date: 10.05.2012 International Filing Date: 24.10.2011
IPC:
A61K 9/107 (2006.01) ,A61K 47/10 (2006.01) ,A61K 47/20 (2006.01) ,A61K 47/26 (2006.01) ,A61K 47/34 (2006.01) ,A61K 47/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
20
containing sulfur
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
26
Carbohydrates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
16
containing nitrogen
18
Amines; Quaternary ammonium compounds
Applicants:
DEVARAJAN, Padma, Venkitachalam [IN/IN]; IN
KAPSE, Sonali, Vithal [IN/IN]; IN
JINDAL, Anil, Brij, Bhushan [IN/IN]; IN
Inventors:
DEVARAJAN, Padma, Venkitachalam; IN
KAPSE, Sonali, Vithal; IN
JINDAL, Anil, Brij, Bhushan; IN
Priority Data:
3055/MUM/201003.11.2010IN
Title (EN) PHARMACEUTICAL COMPOSITIONS FOR COLLOIDAL DRUG DELIVERY
(FR) COMPOSITIONS PHARMACEUTIQUES DESTINÉES À L'ADMINISTRATION DE MÉDICAMENTS COLLOÏDAUX
Abstract:
(EN) The present invention relates to preparation of drug loaded heterogeneous nanosystems resulting from mixing of two monophasic phases, the non-aqueous phase comprising of active agent/s, polymers, lipids, surfactants, solubilizer/s and other excipients and the aqueous phase comprising of buffers, isotonic solutions, sweetners, flavors and other excipients.The novel technique enables formation of stable colloidal particles with high drug loading and predictable size at the time of use. The invention represents a major step in circumventing the technological challenges in the design of colloidal particles which can remain suspended for at least 4h maintaining an effective average particle size of <1μm. The unique delivery system makes part of the active agent/s readily bioavailable and part of the agent is present within the polymeric matrix. The invention is applicable to agent/s that contains electrical group, as the particles are formed due to electrostatic interaction. The novel technique avoids use of organic solvent and can reduce energy requirements compared to the conventional preparation methods. The invention is aimed at the overall improvement of therapeutic efficacy, enhance solubility, enhance oral bioavailability and rapid dissolution for in vivo delivery of the BCS class agent/s. The heterogeneous nanosystems /compositions produced according to the invention can be useful in drug delivery, imaging and diagnosis and can be administered by oral and parenteral route.
(FR) La présente invention concerne la préparation de nanosystèmes hétérogènes chargés en médicament obtenus par mélange de deux phases monophasiques, la phase non-aqueuse comprenant un/des agent(s) actif(s), des polymères, des lipides, des surfactants, un/des agent(s) solubilisant(s) et d'autres excipients et la phase aqueuse comprenant des tampons, des solutions isotoniques, des adoucissants, des arômes et d'autres excipients. La nouvelle technique permet la formation de particules colloïdales stables hautement chargées en médicament et de taille prévisible au moment de leur utilisation. L'invention représente une étape importante dans le contournement des défis technologiques dans la conception de particules colloïdales pouvant rester suspendues durant au moins 4h en conservant une taille moyenne effective des particules <1μm. Le système d'administration unique rend une partie du/des agent(s) actif(s) rapidement biodisponible(s) et une partie de l'agent est présente dans la matrice polymère. L'invention est applicable à l'agent/aux agents qui contient/contiennent un groupe électrique, étant donné que les particules sont formées par interaction électrostatique. La nouvelle technique n'utilise pas de solvant organique et permet de réduire les besoins énergétiques par rapport aux procédés de préparation classique. L'invention vise une amélioration globale de l'efficacité thérapeutique, une amélioration de la solubilité, une amélioration de la biodisponibilité orale et une dissolution rapide pour une administration in vivo du/des agent(s) de classe BCS. Les compositions/nanosystèmes hétérogènes produits selon l'invention sont utiles dans l'administration de médicaments, l'imagerie et le diagnostic et peuvent être administrés par voie orale ou parentérale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)