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1. WO2012059935 - PROCESS FOR PREPARING BENDAMUS TINE HYDROCHLORIDE MONOHYDRATE

Publication Number WO/2012/059935
Publication Date 10.05.2012
International Application No. PCT/IN2011/000585
International Filing Date 29.08.2011
IPC
C07D 235/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
04Benzimidazoles; Hydrogenated benzimidazoles
06with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
16Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
A61K 31/4184 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4184condensed with carbocyclic rings, e.g. benzimidazoles
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/4184
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41641,3-Diazoles
4184condensed with carbocyclic rings, e.g. benzimidazoles
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07C 209/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
04by substitution of functional groups by amino groups
06by substitution of halogen atoms
10with formation of amino groups bound to carbon atoms of six-membered aromatic rings or from amines having nitrogen atoms bound to carbon atoms of six-membered aromatic rings
C07D 235/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
04Benzimidazoles; Hydrogenated benzimidazoles
06with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
16Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applicants
  • SHILPA MEDICARE LIMITED [IN]/[IN] (AllExceptUS)
  • SHRAWAT, Vimal Kumar [IN]/[IN] (UsOnly)
  • PUROHIT, Prashant [IN]/[IN] (UsOnly)
  • SINGH, Vinod Kumar [IN]/[IN] (UsOnly)
  • UNNAM, Seshachalam [IN]/[IN] (UsOnly)
Inventors
  • SHRAWAT, Vimal Kumar
  • PUROHIT, Prashant
  • SINGH, Vinod Kumar
  • UNNAM, Seshachalam
Agents
  • AMBASTHA, Lalit
Priority Data
3261/CHE/201001.11.2010IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PREPARING BENDAMUS TINE HYDROCHLORIDE MONOHYDRATE
(FR) PROCÉDÉ DE SYNTHÈSE DE CHLORHYDRATE DE BENDAMUSTINE MONOHYDRATE
Abstract
(EN)
A process for preparing Bendamustine hydrochloride monohydrate is provided. A process for purifying said monohydrate to get substantially purne Bendamustine hydrochloride monohydrate crystalline form is also provided.
(FR)
La présente invention concerne un procédé de synthèse de chlorhydrate de Bendamustine monohydrate. La présente invention concerne également un procédé de purification dudit monohydrate pour obtenir une forme cristalline de chlorhydrate de Bendamustine monohydrate essentiellement pure.
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