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1. WO2012059926 - PLANT EXTRACTS FOR TREATING BURNS AND CHRONIC WOUNDS

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[ EN ]

1. A composition comprising as an active ingredient an oil extract or oily suspension of a combination of ground roots of Harpagophytum procumbens (Devil's claw) and Angelica archangelica (Angelica).

2. The composition of claim 1, wherein the active ingredient further comprises an oil extract or oily suspension of ground roots of Hydrastis canadensis (Golden Seal).

3. The composition of claim 1, further comprising an oil extract or oily suspension of at least one of ground root of Astragalus membranaceous (Astragalus); ground leaves of Symphytum officinale (Comfrey) ground leaves of Urtica dioica (Stinging Nettle) or any combination thereof.

4. The Composition of claim 3, further comprising an oil extract or oily suspension of ground leaves of Agrimonia Eupatoria (Agrimony) and ground blue-green algae.

5. The composition of claim 4 comprising as an active ingredient an oil extract or oily suspension of a combination of ground plant material comprising roots of Harpagophytum procumbens (Devil's claw), Angelica Archangelica (Angelica) and Astragalus membranaceous (Astragalus); leaves of Symphytum officinale (Comfrey), Urtica dioica (Stinging Nettle) and Agrimonia Eupatoria (Agrimony); and blue- green algae.

6. The composition of claim 5, wherein the active ingredient further comprises an oil extract or oily suspension of ground roots of Hydrastis Canadensis (Golden Seal).

7. The composition of claim 5, consisting of an oil extract or oily suspension of a combination of ground plant material consisting of roots of Harpagophytum procumbens (Devil's claw), Angelica Archangelica (Angelica) and Astragalus membranaceous (Astragalus); leaves of Symphytum officinale (Comfrey), Urtica dioica (Stinging Nettle) and Agrimonia Eupatoria (Agrimony); and ground blue- green algae.

8. A composition consisting of an oil extract or oily suspension of a combination of ground plant material consisting of roots of Harpagophytum procumbens (Devil's claw), Angelica Archangelica (Angelica), Hydrastis Canadensis (Golden Seal), and Astragalus membranaceous (Astragalus); leaves of Symphytum officinale (Comfrey), Urtica dioica (Stinging Nettle) and Agrimonia Eupatoria (Agrimony); and ground blue-green algae.

9. The composition of any one of claims 1-8 wherein the oil is selected from the group consisting of a mineral oil, a vegetable oil and combinations thereof.

10. The composition of claim 9, wherein the oil is a vegetable oil selected from the group consisting of wheat germ oil, almond oil, canola oil, coconut oil, corn oil, cottonseed oil, grape seed oil, olive oil peanut oil, saffron oil, sesame oil, soybean oil, and combinations thereof.

1 1. The composition of claim 10, wherein the oil is wheat germ oil.

12. The composition of any one of claims 1-8, wherein the plant material is in a dry form.

13. The composition of claim 12, wherein the dry material is ground to a fine powder.

14. The composition of any one of claims 1-8, further comprising at least one additional active ingredient selected from the group consisting of an antiinflammatory agent, analgesic agent, anesthetic agent, antihistamine, disinfectant, antibiotic agent and a drug effective in wound healing.

15. A pharmaceutical or dermatological composition comprising the composition of any one of claims 1-8, further comprising a pharmaceutically or dermatologically acceptable diluent, excipient or carrier.

16. The pharmaceutical or dermatological composition of claim 15, further comprising an additive selected from the group consisting of fats, emulsifiers, co- emulsifiers, hydrophilic or lipophilic gelling agents, preservatives, solvents, fragrances, fillers, hydrophilic and lipophilic filters, neutralizers, penetration- enhancing agents and polymers.

17. The pharmaceutical or dermatological composition of claim 15, formulated for topical administration onto a wound.

18. The pharmaceutical or dermatological composition of claim 15, formulated for topical administration by injection into a wound.

19. A method for treating a burn or chronic wound comprising topically administering to a subject in need thereof an effective amount of a composition according to any one of claims 1-8 or 15.

20. The method of claim 19, further comprising covering the treated wound or burn area with a wound dressing.

21. The method of claim 20, wherein the composition is spread onto the wound or burn.

22. The method of claim 19 wherein the composition is spread on the wound dressing.

23. The method of claim 19, wherein the composition is injected into the wound.

24. The method of claim 19, wherein the composition is administered once in 4-7 days for at least two weeks.

25. The method of claim 24, wherein the composition is administered once in 4-7 days for about 14-70 days.

26. The method of claim 19, wherein the wound is selected from the group consisting of full and partial thickness burn wounds, sunburns, frostbite, ulcerative lesions, wounds associated with surgical procedures, traumatic and pyogenic wounds; varicose, vaginitis; cervicitis; pilonidal cyst wounds; pathological fissure and pathological hemorrhoids.

27. The method of claim 19 wherein the wound is associated with states in which the normal wound repair ability is weakened.

28. The method of claim 27, wherein the wound is associated with a state selected from the group consisting of diabetes; an older age patient, steroid treatment and chemotherapy.

29. The method of claim 28, wherein the wound is selected from the group consisting of diabetic foot ulcers, neuropathic ulcers, diabetic pressure ulcers, diabetic venous ulcers; bed sores associated with long-term disability and pressure ulcers.