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1. WO2012059745 - FLUOROMETRY

Publication Number WO/2012/059745
Publication Date 10.05.2012
International Application No. PCT/GB2011/052114
International Filing Date 31.10.2011
IPC
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
CPC
G01N 21/6408
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6408with measurement of decay time, time resolved fluorescence
G01N 21/645
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
Applicants
  • THOMPSON, Edward John [US]/[GB]
  • TAL, Ilan [US]/[IL] (UsOnly)
Inventors
  • THOMPSON, Edward John
  • TAL, Ilan
Priority Data
1018361.401.11.2010GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FLUOROMETRY
(FR) FLUORIMÉTRIE
Abstract
(EN)
The invention relates to fluorometry, and in particular to methods and apparatus for time- delayed detection of fluorescence in a sample, for example for use in a clinical setting. Exemplary embodiments disclosed relate to a fluorometer (100) comprising a light source (101), a light detector (102), a sample holder (103) disposed between the light source and light detector, a motor (104); and a light transmission modulator (105) disposed around the sample holder and comprising a pair of plates (106, 107) attached to the motor for rotation about a common axis (108), the pair of plates arranged to allow transmission from the source to the sample in a first rotated position, to allow transmission from the sample to the detector in a second rotated position and to block direct light transmission between the source and detector in both first and second rotated positions. Light signal data may be captured after stopping operation of the motor and while the light transmission modulator is rotating in order to reduce or eliminate electrical noise and mechanical vibrations from the motor.
(FR)
La présente invention concerne la fluorimétrie et, notamment, des procédés et un appareil destinés à la détection retardée de la fluorescence dans un échantillon, par exemple à utiliser en milieu clinique. Des exemples de modes de réalisation divulgués concernent un fluorimètre (100) qui comprend une source de lumière (101), un détecteur de lumière (102), un porte-échantillon (103) disposé entre la source de lumière et le détecteur de lumière, un moteur (104); et un modulateur de transmission lumineuse (105) disposé autour du porte-échantillon et qui comprend une paire de plaques (106, 107) fixées au moteur de manière qu'elles tournent autour d'un axe commun (108), la paire de plaques étant agencée pour permettre la transmission, de la source à l'échantillon dans une première position de rotation, pour permettre la transmission de l'échantillon au détecteur dans une seconde position de rotation et pour bloquer la transmission lumineuse directe entre la source et le détecteur à la fois dans la première et la seconde position de rotation. Des données de signal lumineux peuvent être capturées après l'arrêt du moteur et pendant que le modulateur de transmission lumineuse est en rotation, de manière que le bruit électrique et les vibrations mécaniques provenant du moteur soient réduits ou éliminés.
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