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1. WO2012059576 - CEST SYSTEMS EXHIBITING A CONCENTRATION INDEPENDENT RESPONSIVENESS

Publication Number WO/2012/059576
Publication Date 10.05.2012
International Application No. PCT/EP2011/069406
International Filing Date 04.11.2011
IPC
A61K 49/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08characterised by the carrier
10Organic compounds
G01R 33/48 2006.01
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance
48NMR imaging systems
CPC
A61K 49/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
10Organic compounds
A61K 49/101
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
10Organic compounds
101the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
A61K 49/106
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
10Organic compounds
101the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
106the complex-forming compound being cyclic, e.g. DOTA
A61K 49/108
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
10Organic compounds
101the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
106the complex-forming compound being cyclic, e.g. DOTA
108the metal complex being Gd-DOTA
A61K 49/124
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
10Organic compounds
12Macromolecular compounds
124dendrimers, dendrons, hyperbranched compounds
G01R 33/48
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
48NMR imaging systems
Applicants
  • Bracco Imaging SpA [IT]/[IT]
  • AIME, Silvio [IT]/[IT] (UsOnly)
  • TERRENO, Enzo [IT]/[IT] (UsOnly)
  • DELLI CASTELLI, Daniela [IT]/[IT] (UsOnly)
  • LONGO, Dario Livio [IT]/[IT] (UsOnly)
  • FEDELI, Franco [IT]/[IT] (UsOnly)
  • UGGERI, Fulvio [IT]/[IT] (UsOnly)
Inventors
  • AIME, Silvio
  • TERRENO, Enzo
  • DELLI CASTELLI, Daniela
  • LONGO, Dario Livio
  • FEDELI, Franco
  • UGGERI, Fulvio
Agents
  • MERLI, Silvia
Priority Data
10190161.905.11.2010EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CEST SYSTEMS EXHIBITING A CONCENTRATION INDEPENDENT RESPONSIVENESS
(FR) SYSTÈMES CEST PRÉSENTANT UNE SENSIBILITÉ INDÉPENDANTE DE LA CONCENTRATION
Abstract
(EN)
The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
(FR)
La présente invention concerne l'utilisation de protons mobiles non équivalents appartenant à des stéréoisomères pouvant être distingués par RMN d'un agent CEST dans une procédure d'imagerie CEST à base logométrique, et des composés de complexe de Lanthanide (III) présentant au moins deux stéréoisomères pouvant être distingués par RMN en solution, utiles en tant qu'agents de réponse CEST indépendants de la concentration.
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