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1. WO2012059024 - 2-CHLORO-SUBSTITUTED OR UNSUBSTITUTED ALIPHATIC HYDROCARBYLOXY-PYRIDINE AND PREPARATION METHOD THEREOF

Publication Number WO/2012/059024
Publication Date 10.05.2012
International Application No. PCT/CN2011/081471
International Filing Date 28.10.2011
IPC
C07D 213/64 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62Oxygen or sulfur atoms
63One oxygen atom
64attached in position 2 or 6
C07D 213/643 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62Oxygen or sulfur atoms
63One oxygen atom
64attached in position 2 or 6
6432-Phenoxypyridines; Derivatives thereof
CPC
C07D 213/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62Oxygen or sulfur atoms
63One oxygen atom
64attached in position 2 or 6
C07D 213/643
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62Oxygen or sulfur atoms
63One oxygen atom
64attached in position 2 or 6
6432-Phenoxypyridines; Derivatives thereof
Applicants
  • 重庆康丁医药技术有限公司 CHONGQING KENTSON MED. & PHARM. TECH, LTD. [CN]/[CN] (AllExceptUS)
  • 谢方 XIE, Fang [CN]/[CN] (UsOnly)
Inventors
  • 谢方 XIE, Fang
Agents
  • 北京龙双利达知识产权代理有限公司 LONGSUN LEAD IP LTD.
Priority Data
201010526260.401.11.2010CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) 2-CHLORO-SUBSTITUTED OR UNSUBSTITUTED ALIPHATIC HYDROCARBYLOXY-PYRIDINE AND PREPARATION METHOD THEREOF
(FR) HYDROCARBYLOXY-PYRIDINE ALIPHATIQUE À SUBSTITUTION 2-CHLORO OU NON SUBSTITUÉ, ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 2-氯-6-取代或未取代烃氧基吡啶及其制备方法
Abstract
(EN)
Disclosed are 2-chloro-6-substituted or unsubstituted hydrocarbyloxy- pyridine compounds represented by formula (I) and preparation method thereof, wherein R is an unsubstituted or substituted aliphatic hydrocarbyl group or phenyl group, preferably R is an unsubstituted or substituted lower alkyl group or phenyl group. The method comprises subjecting 2,6-dichloropyridine to substitution reaction with [RO-]aMa+ to generate a compound represented by formula (I); wherein M is an alkali metal or alkali earth metal, wherein a is 1 or 2.
(FR)
La présente invention concerne des composés hydrocarbyloxy-pyridine à substitution 2-chloro-6 ou non substitués, représentés par la formule (I), et leur procédé de préparation. Dans ladite formule, R est un groupe phényle ou un groupe hydrocarbyle aliphatique substitué ou non substitué, et de préférence R est un groupe phényle ou un groupe alkyle inférieur substitué ou non substitué. Ledit procédé comprend la soumission de 2,6-dichloropyridine à une réaction de substitution avec [RO-]aMa+ pour produire un composé représenté par la formule (I), M étant un métal alcalin ou un métal alcalino-terreux, et a étant égal à 1 ou 2.
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