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1. WO2012058866 - BENZAMIDE DERIVATIVE WITH ANTICANCER ACTIVITY AND PREPARATION METHOD AND USE THEREOF

Publication Number WO/2012/058866
Publication Date 10.05.2012
International Application No. PCT/CN2011/001854
International Filing Date 03.11.2011
IPC
C07C 233/65 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
65having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
C07C 233/92 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
90having nitrogen atoms of carboxamide groups further acylated
92with at least one carbon atom of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07C 231/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
02from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
C07C 231/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
12by reactions not involving the formation of carboxamide groups
C07C 271/64 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
62Compounds containing any of the groups X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
64Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
C07C 269/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
269Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
04from amines with formation of carbamate groups
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Applicants
  • 浙江海正药业股份有限公司 ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. [CN]/[CN] (AllExceptUS)
  • 白骅 BAI, Hua [CN]/[CN] (UsOnly)
  • 赵旭阳 ZHAO, Xuyang [CN]/[CN] (UsOnly)
  • 龚永祥 GONG, Yongxiang [CN]/[CN] (UsOnly)
  • 钟金清 ZHONG, Jinqing [CN]/[CN] (UsOnly)
  • 朱齐凤 ZHU, Qifeng [CN]/[CN] (UsOnly)
  • 刘晓宇 LIU, Xiaoyu [CA]/[CN] (UsOnly)
  • 刘礼飞 LIU, Lifei [CN]/[CN] (UsOnly)
  • 周其贤 ZHOU, Qixian [CN]/[CN] (UsOnly)
Inventors
  • 白骅 BAI, Hua
  • 赵旭阳 ZHAO, Xuyang
  • 龚永祥 GONG, Yongxiang
  • 钟金清 ZHONG, Jinqing
  • 朱齐凤 ZHU, Qifeng
  • 刘晓宇 LIU, Xiaoyu
  • 刘礼飞 LIU, Lifei
  • 周其贤 ZHOU, Qixian
Priority Data
201010532658.905.11.2010CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) BENZAMIDE DERIVATIVE WITH ANTICANCER ACTIVITY AND PREPARATION METHOD AND USE THEREOF
(FR) DÉRIVÉ BENZAMIDE DOTÉ D'UNE ACTIVITÉ ANTICANCÉREUSE, PROCÉDÉ D'ÉLABORATION, ET UTILISATION CORRESPONDANTE
(ZH) 具有抗癌活性的苯甲酰胺衍生物及其制备方法和用途
Abstract
(EN)
Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula (I) are as set out in the description.
(FR)
La présente invention concerne un dérivé benzamide représenté par la formule (I) ou l'un de ses sels pharmaceutiquement admis. L'invention concerne également le procédé d'élaboration et l'utilisation de ceux-ci pour l'élaboration d'un médicament destiné à traiter le cancer, les groupes de la formule (I) étant tels que définis dans la description.
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