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1. WO2012058665 - COMPOSITIONS AND METHODS FOR MODULATION AND DETECTION OF IMMUNE AND INFLAMMATORY RESPONSES

Publication Number WO/2012/058665
Publication Date 03.05.2012
International Application No. PCT/US2011/058551
International Filing Date 31.10.2011
IPC
C07K 16/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
A61K 39/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
A61K 39/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
40bacterial
C07K 16/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
12against material from bacteria
C07K 16/44
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
44against material not provided for elsewhere ; , e.g. haptens, metals, DNA, RNA, amino acids
G01N 2333/195
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
195from bacteria
G01N 2405/04
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2405Assays, e.g. immunoassays or enzyme assays, involving lipids
04Phospholipids, i.e. phosphoglycerides
Applicants
  • UNIVERSITY OF CONNECTICUT [US]/[US] (AllExceptUS)
  • CLARK, Robert, B. [US]/[US] (UsOnly)
  • NICHOLS, Frank, C. [US]/[US] (UsOnly)
Inventors
  • CLARK, Robert, B.
  • NICHOLS, Frank, C.
Agents
  • PRATT, John, S.
Priority Data
61/455,96729.10.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR MODULATION AND DETECTION OF IMMUNE AND INFLAMMATORY RESPONSES
(FR) COMPOSITIONS ET PROCÉDÉS POUR MODULATION ET DÉTECTION DE RÉPONSES IMMUNITAIRES ET INFLAMMATOIRES
Abstract
(EN)
A method for detecting an inflammatory or an autoimmune condition, comprising analyzing bacterial lipids, such as phosphorylated dihydroceramides (PDHC), in a sample; and, comparing results of the analysis of the bacterial lipids in the sample with information on occurrence of the bacterial lipids in a comparable sample, wherein the comparison is indicative of the inflammatory or the autoimmune condition. An example of the autoimmune condition is multiple sclerosis. According to one embodiment, an increased ratio of phosphoglycerol dihydroceramide (PG DHC) to phosphoethanolamine dihydroceramide (PE DHC) in a blood sample indicates a presence of MS in the source patient. The use of PDHCs as biomarkers for detection of MS is described. Antibodies specific to PG DHC or PE DHC are also provided, along with their uses. Also provided are compositions comprising bacteria-originated lipids useful for modulation of immune responses or TLR pathaways in humans, animals, and human or animal cells or tissues.
(FR)
La présente invention concerne un procédé pour détecter une affection inflammatoire ou auto-immune, comprenant l'analyse de lipides bactériens, tels que des dihydrocéramides phosphorylés (PDHC), dans un échantillon; et, la comparaison des résultats de l'analyse des lipides bactériens dans l'échantillon avec des informations sur l'occurrence des lipides bactériens dans un échantillon comparable, la comparaison étant indicatrice de l'affection inflammatoire ou auto-immune. Un exemple d'affection auto-immune est la sclérose en plaques. Selon un mode de réalisation, un rapport augmenté du phosphoglycérol-dihydrocéramide (PG-DHC) au phosphoéthanolamine-dihydrocéramide (PE-DHC) dans un échantillon de sang indique une présence de sclérose en plaques chez le patient source. La présente invention concerne en outre l'utilisation de PDHC en tant que biomarqueurs pour la détection de la sclérose en plaques. La présente invention concerne en outre des anticorps spécifiques pour PG-DHC ou PE-DHC, ainsi que leurs utilisations. La présente invention concerne en outre des compositions comprenant des lipides d'origine bactérienne utiles pour la modulation de réponses immunitaires ou des voies TLR chez des humains, des animaux, et des cellules ou tissus humains ou animaux.
Also published as
Latest bibliographic data on file with the International Bureau