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1. WO2012058464 - MULTIPHASIC POLYMERIC PARTICLES CAPABLE OF SHAPE-SHIFTING VIA ENVIRONMENTAL STIMULATION

Publication Number WO/2012/058464
Publication Date 03.05.2012
International Application No. PCT/US2011/058142
International Filing Date 27.10.2011
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
C08J 3/00 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H142
3Processes of treating or compounding macromolecular substances
C09K 3/00 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
KMATERIALS FOR APPLICATIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
3Materials not provided for elsewhere
G01N 33/48 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
B01J 19/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
CPC
A61K 9/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
A61K 9/1647
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1641obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
1647Polyesters, e.g. poly(lactide-co-glycolide)
Applicants
  • THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]/[US] (AllExceptUS)
  • LAHANN, Joerg [DE]/[US] (UsOnly)
  • YOON, Jaewon [KR]/[US] (UsOnly)
  • BHASKAR, Srijanani [IN]/[US] (UsOnly)
  • LEE, Kyungjin [KR]/[US] (UsOnly)
Inventors
  • LAHANN, Joerg
  • YOON, Jaewon
  • BHASKAR, Srijanani
  • LEE, Kyungjin
Agents
  • WOODSIDE-WOJTALA, Jennifer
Priority Data
61/407,79328.10.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MULTIPHASIC POLYMERIC PARTICLES CAPABLE OF SHAPE-SHIFTING VIA ENVIRONMENTAL STIMULATION
(FR) PARTICULES POLYMÈRES MULTIPHASES CAPABLES DE CHANGER DE FORME EN FONCTION DE STIMULI ENVIRONNEMENTAUX
Abstract
(EN)
Provided herein are methods of making and controlling multiphasic polymeric micro-components capable of shape-shifting. Such a multiphasic micro-component comprises a first phase (that can include a first polymer) and at least one additional phase distinct from said first phase (that can include a second polymer). One or more of the first phase and additional phase comprises a component that is responsive to an external stimulus. Thus, the micro-component exhibits a substantial physical deformation in response to: (i) the presence of the external stimulus or (ii) a change in the external stimulus. Exemplary external stimuli include temperature, pressure, light, pH, ionic strength, hydrophobicity/hydrophilicity, solvent, concentration, a stimulator chemical, sonic energy, electric energy, pressure, magnetic fields, and combinations thereof.
(FR)
Cette invention concerne des procédés de fabrication et de contrôle de micro-composants polymères multiphases capables de changer de forme. Ces micro-composants multiphases comprennent une première phase (pouvant comporter un premier polymère) et au moins une deuxième phase (pouvant comporter un deuxième polymère) distincte de ladite première phase. La première phase et/ou la deuxième phase comprennent un composant sensible à un stimulus externe. Le micro-composant présente une déformation physique importante en réponse à : (i) la présence du stimulus externe ou (ii) un changement du stimulus externe. Parmi les stimuli externes figurent la température, la pression, la lumière, le pH, la force ionique, le caractère hydrophobe/hydrophile, le solvant, la concentration, un stimulateur chimique, l'énergie sonique, l'énergie électrique, la pression, les champs magnétiques et leurs associations.
Also published as
Latest bibliographic data on file with the International Bureau