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1. WO2012058176 - NOVEL HETEROARYL-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS

Publication Number WO/2012/058176
Publication Date 03.05.2012
International Application No. PCT/US2011/057561
International Filing Date 25.10.2011
IPC
A61K 31/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
A61K 31/445 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
A61K 31/425 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
CPC
A61K 31/425
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
A61K 31/445
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US] (AllExceptUS)
  • PALIWAL, Sunil [US]/[US] (UsOnly)
  • TSUI, Hon-Chung [CN]/[US] (UsOnly)
  • GAO, Xiaolei [CN]/[US] (UsOnly)
  • KIM, Hyunjin, M. [US]/[US] (UsOnly)
  • CAPLEN, Mary Ann [US]/[US] (UsOnly)
  • FISCHMANN, Thierry, O. [US]/[US] (UsOnly)
  • DUCA, Jose, S. [AR]/[US] (UsOnly)
Inventors
  • PALIWAL, Sunil
  • TSUI, Hon-Chung
  • GAO, Xiaolei
  • KIM, Hyunjin, M.
  • CAPLEN, Mary Ann
  • FISCHMANN, Thierry, O.
  • DUCA, Jose, S.
Agents
  • LEFF, Matthew, A.
Priority Data
61/408,15929.10.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL HETEROARYL-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS
(FR) NOUVEAUX DÉRIVÉS DE HÉTÉROARYL-CARBOXAMIDE UTILISÉS COMME INHIBITEURS DE LA PDK1
Abstract
(EN)
This invention relates to certain Heteroaryl Carboxamide derivatives of Formula (I) as inhibitors of 3-phosphoinositide-dependent protein kinase (PDK-1). The compounds can be useful in inhibiting the proliferation of cancer cells, and other aberrant conditions where the PDK-1 signaling pathway is overstimulated.
(FR)
L'invention concerne certains dérivés de hétéroaryl-carboxamide de la formule (I) utilisés comme inhibiteurs de la protéine kinase-3-phosphoinositide-dépendante (PDK-1). Ces composés peuvent être utiles pour inhiber la prolifération des cellules cancéreuses, et d'autres états aberrants dans lesquels la voie de transmission des signaux de la PDK-1 est surstimulée.
Also published as
Latest bibliographic data on file with the International Bureau