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1. WO2012058133 - ISOINDOLINONE PDE10 INHIBITORS

Publication Number WO/2012/058133
Publication Date 03.05.2012
International Application No. PCT/US2011/057420
International Filing Date 24.10.2011
IPC
A61K 31/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
CPC
A61K 31/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
C07D 403/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 413/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
14containing three or more hetero rings
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US] (AllExceptUS)
  • BUNDA, Jaime, L. [US]/[US] (NZ, US)
  • COX, Christopher, D. [US]/[US] (NZ, US)
  • DUDKIN, Vadim, Y. [RU]/[US] (NZ, US)
  • FIJI, Hannah, D. [US]/[US] (NZ, US)
  • KELLY, Michael, J., III [US]/[US] (NZ, US)
  • LAYTON, Mark, E. [US]/[US] (NZ, US)
  • PERO, Joseph, E. [US]/[US] (NZ, US)
  • SHIPE, William, D. [US]/[US] (NZ, US)
  • STEEN, Justin, T. [US]/[US] (NZ, US)
Inventors
  • BUNDA, Jaime, L.
  • COX, Christopher, D.
  • DUDKIN, Vadim, Y.
  • FIJI, Hannah, D.
  • KELLY, Michael, J., III
  • LAYTON, Mark, E.
  • PERO, Joseph, E.
  • SHIPE, William, D.
  • STEEN, Justin, T.
Common Representative
  • MERCK SHARP & DOHME CORP.
Priority Data
61/408,08229.10.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ISOINDOLINONE PDE10 INHIBITORS
(FR) COMPOSÉS D'ISOINDOLINONE UTILES COMME INHIBITEURS DE PDE 10
Abstract
(EN)
The present invention is directed to isoindolinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
(FR)
La présente invention concerne des composés d'isoindolinone qui sont utiles comme agents thérapeutiques pour le traitement des troubles du système nerveux central associés à la phosphodiesterase 10 (PDE10). La présente invention concerne également l'utilisation de ces composés dans le traitement de troubles neurologiques et psychiatriques, tels que la schizophrénie, la psychose ou la maladie de Huntington, et ceux associés à l'hypofonctionnement striatal ou au dysfonctionnement des noyaux gris centraux.
Also published as
Latest bibliographic data on file with the International Bureau