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1. WO2012056451 - PERIPHERAL BLOOD GENE MARKERS FOR EARLY DIAGNOSIS OF PARKINSON'S DISEASE

Publication Number WO/2012/056451
Publication Date 03.05.2012
International Application No. PCT/IL2011/000830
International Filing Date 26.10.2011
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/686
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6844Nucleic acid amplification reactions
686Polymerase chain reaction [PCR]
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
G16B 25/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
25ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
Applicants
  • MANDEL, Silvia A [IL]/[IL]
  • YOUDIM, Moussa B.H. [IL]/[IL]
  • RIEDERER, Peter [AT]/[DE]
  • GRUNBLATT, Edna [CH]/[CH]
  • RABEY, Jose M. [IL]/[IL]
  • MOLOCHNIKOV, Leonid [IL]/[IL]
Inventors
  • MANDEL, Silvia A
  • YOUDIM, Moussa B.H.
  • RIEDERER, Peter
  • GRUNBLATT, Edna
  • RABEY, Jose M.
  • MOLOCHNIKOV, Leonid
Agents
  • BEN-AMI & ASSOCIATES
Priority Data
61/406,78226.10.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PERIPHERAL BLOOD GENE MARKERS FOR EARLY DIAGNOSIS OF PARKINSON'S DISEASE
(FR) MARQUEURS GÉNIQUES DU SANG PÉRIPHÉRIQUE DESTINÉS AU DIAGNOSTIC PRÉCOCE DE LA MALADIE DE PARKINSON
Abstract
(EN)
The present invention relates to the use of molecular risk marker profiles for diagnosis of Parkinson's disease. More particularly, the invention provides methods for diagnosis of Parkinson's disease in an individual, utilizing certain profiles established based on the expression levels of certain genes, which together form a gene panel, in the peripheral blood of said individual, as well as kits for carrying out these methods. The profile encompass ALDH1A1.
(FR)
La présente invention concerne l'utilisation de profils de marqueur de risque moléculaire pour le diagnostic de la maladie de Parkinson. Elle concerne, plus particulièrement, des procédés de diagnostic de la maladie de Parkinson chez un individu, au moyen de certains profils établis sur la base des niveaux d'expression de certains gènes, qui forment ensemble un panel de gènes, dans le sang périphérique de l'individu, ainsi que des nécessaires destinés à mettre en oeuvre ces procédés.
Latest bibliographic data on file with the International Bureau