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1. WO2012056236 - ANALYTICAL METHODS AND ARRAYS FOR USE IN THE IDENTIFICATION OF AGENTS INDUCING SENSITIZATION IN HUMAN SKIN

Publication Number WO/2012/056236
Publication Date 03.05.2012
International Application No. PCT/GB2011/052082
International Filing Date 26.10.2011
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/6876
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/148
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
148Screening for cosmetic compounds
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
G01N 33/5023
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5008for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
502for testing non-proliferative effects
5023on expression patterns
G01N 33/5044
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5008for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
5044involving specific cell types
Applicants
  • SENZAGEN AB [SE]/[SE] (AllExceptUS)
  • SMITH, Stephen Edward [GB]/[GB] (MN)
  • LINDSTEDT, Malin [SE]/[SE] (UsOnly)
  • BORREBAECK, Carl A K [SE]/[SE] (UsOnly)
  • JOHANSSON, Henrik [SE]/[SE] (UsOnly)
  • ALBREKT, Ann-Sofie [SE]/[SE] (UsOnly)
Inventors
  • LINDSTEDT, Malin
  • BORREBAECK, Carl A K
  • JOHANSSON, Henrik
  • ALBREKT, Ann-Sofie
Agents
  • SMITH, Stephen Edward
Priority Data
1018014.926.10.2010GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANALYTICAL METHODS AND ARRAYS FOR USE IN THE IDENTIFICATION OF AGENTS INDUCING SENSITIZATION IN HUMAN SKIN
(FR) PROCÉDÉS D'ANALYSE ET PUCES UTILISABLES À CET EFFET
Abstract
(EN)
The present invention relates to an in vitro method for identifying agents capable of inducing sensitization of human skin and arrays and diagnostic kits for use in such methods. In particular, the methods include measurement of the expression of the biomarkers listed in Table 3A and/or 3B in MUTZ-3 cells exposed to a test agent.
(FR)
La présente invention concerne un procédé in vitro d'identification d'agents capables d'induire une sensibilisation de la peau humaine, ainsi que des puces et des nécessaires de diagnostic utilisables dans lesdits procédés. Lesdits procédés comprennent, en particulier, la mesure de l'expression, dans des cellules MUTZ-3 exposées à un agent d'essai, des biomarqueurs énumérés dans le tableau 3A et/ou 3B.
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