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1. WO2012056223 - A DIAGNOSTIC DEVICE

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[ EN ]

CLAIMS

1. An ingestible diagnostic device comprising detection means for detecting gases and/or volatile organic compounds (VOCs).

2. A device according to claim 1, wherein the device is capable of detecting and characterising gases and other VOCs present in the gastrointestinal tract in vivo, for diagnosing disease.

3. A device according to either claim 1 or claim 2, wherein the detection means is capable of detecting nitrous oxide, hydrogen sulphide, carbon dioxide, hydrogen ethanoic, butanoic and pentanoic acids, benzaldehyde, ethanal, carbon disulfide, dimethyldisulfide, acetone, 2-butanone, 2,3-butanedione, 6-methyl-5-hepten-2-one, indole and/ or 4-methylphenol.

4. A device according to any preceding claim, wherein the detection means comprises one or more chemical sensors, which are capable of detecting gas and/ or VOCs emitted from the gastrointestinal tract of the subject.

5. A device according to any preceding claim, wherein the detection means detects gas and/ or VOC using technology selected from the group consisting of: resistive metal oxide; resistive mixed metal oxide; electrochemical sensors; resistive/ capacitive/ frequency measurement of conducting polymers; resistive/ capacitive/ frequency measurement of composite polymers; optical measurement using infra-red; frequency measurement quartz crystal micro-balances/ shear horizontal surface acoustic wave sensors; gas thermal measurement using pellisters/ calorimetric technology; and thermal measurement techniques using a thermal conductivity sensor and bio-sensor.

6. A device according to any preceding claim, wherein the detection means is internal or external.

7. A device according to any preceding claim, wherein the detection means is disposed on or towards the surface of the device.

8. A device according to any preceding claim, wherein the device comprises a gas permeable membrane or layer, which substantially surrounds the detection means.

9. A device according to claim 8, wherein the membrane is adapted to allow gas and VOCs to pass therethrough and reach the detection means, but prevents bodily fluids or solids from reaching the detection means.

10. A device according to any preceding claim, wherein the detection means is disposed inside the device.

11. A device according to any preceding claim, wherein the device comprises at least one channel, a first end of which is connected to an aperture disposed on the outer surface of the device, and a second end of which is arranged such that it is at least adjacent the detection means.

12. A device according to claim 11, wherein gas and VOCs emitted by the subject pass through the aperture and along the channel, such that it is fed to the detection means.

13. A device according to any preceding claim, wherein the device comprises position sensing means, which is capable of determining the location of the device when ingested by the subject.

14. A device according to any preceding claim, wherein the device comprises a camera, which is capable of taking still images and/ or video footage.

15. A device according to any preceding claim, wherein the device comprises means for detecting pH.

16. A device according to any preceding claim, wherein the device comprises means for detecting temperature.

17. A device according to any preceding claim, wherein the device comprises means for detecting dissolved oxygen concentration.

18. A device according to any preceding claim, wherein the device comprises means for detecting thermal conductivity.

19. A device according to any preceding claim, wherein the device comprises means for detecting the reactance of the bodily fluid.

20. A device according to any preceding claim, wherein the device comprises means for detecting physical properties of the bodily fluid, such as viscosity.

21. A device according to any preceding claim, wherein the device comprises processing means, for processing output data from the detection means.

22. A device according to any preceding claim, wherein the device comprises memory, such as a memory chip, in which output data from the detection means may be stored.

23. A device according to any preceding claim, wherein the device comprises a power source, for example a battery.

24. A device according to any preceding claim, wherein the device comprises a transmitter for transmitting the output data from the detection means, either continuously or intermittently.

25. A device according to claim 24, wherein, where the output data are transmitted via a transmitter, the output data are received by a receiver.

26. An apparatus for diagnosing disease, the apparatus comprise the diagnostic device according to any one of claims 1 to 25 of the first aspect, and a receiver.

27. An apparatus according to claim 26, wherein the receiver is arranged, in use, to receive output data transmitted by the transmitter.

28. Use of the diagnostic device according to any one of claims 1 to 25 or the apparatus according to either claim 26 or 27, for diagnosing disease in a subject.

29. A method of diagnosing disease in a subject, the method comprising: (i) administering, to a subject requiring diagnosis, an ingestible diagnostic device comprising detection means for detecting gases and/ or volatile organic compounds (V OCs); (ii) detecting gases and/ or VOCs emitted by the subject by the detection means; and (iii) providing a diagnosis based on the detected gases and/ or VOCs.

30. Use of claim 28 or the method of claim 29, for detecting gastrointestinal disease, chronic liver disease, or pulmonary, localised or systemic infections, diabetes, obesity or impaired glucose tolerance.