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1. WO2012055994 - PROCESS FOR PREPARING OLMESARTAN MEDOXOMIL

Publication Number WO/2012/055994
Publication Date 03.05.2012
International Application No. PCT/EP2011/068963
International Filing Date 28.10.2011
IPC
C07D 405/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
CPC
C07D 405/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
Applicants
  • INTERQUIM, S.A. [ES]/[ES] (AllExceptUS)
  • JOVÉ MARTÍ, Iban [ES]/[ES] (UsOnly)
  • MARQUILLAS OLONDRIZ, Francisco [ES]/[ES] (UsOnly)
Inventors
  • JOVÉ MARTÍ, Iban
  • MARQUILLAS OLONDRIZ, Francisco
Agents
  • ZBM PATENTS- ZEA, BARLOCCI & MARKVARDSEN
Priority Data
P 20103159729.10.2010ES
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PREPARING OLMESARTAN MEDOXOMIL
(FR) PROCÉDÉ DE PRÉPARATION D'OLMÉSARTAN MÉDOXOMIL
Abstract
(EN)
The invention relates to a process for preparing olmesartan medoxomil by the reaction of sodium 5-(1-hydroxy-1-methylethyl)-2-propyl-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylate, obtained by the reaction between ethyl 5-(1-hydroxy-1-methylethyl)-2-propyl-3H-imidazole-4- carboxylate from and 5-(4'-bromomethylbiphenyl-2-yl)-1-trityl-1H-tetrazole followed by saponification, with 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one, deprotection and purification.
(FR)
La présente invention concerne un procédé de préparation d'olmésartan médoxomil par réaction de 5-(1-hydroxy-1-méthyléthyl)-2-propyl-3-[2'-(1-trityl-1H-tétrazol-5-yl)-biphényl-4-ylméthyl]-3H-imidazole-4-carboxylate de sodium, obtenu par la réaction entre le 5-(1-hydroxy-1-méthyléthyl)-2-propyl-3H-imidazole-4-carboxylate d'éthyle et le 5-(4'-bromométhylbiphényl-2-yl)-1-trityl-1H-tétrazole, suivie d'une saponification, avec la 4-(chlorométhyl)-5-méthyl-1,3-dioxol-2-one, d'une déprotection et d'une purification.
Also published as
EP2011779615
Latest bibliographic data on file with the International Bureau