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1. WO2012055096 - PREPARATION METHOD AND USE OF ANTI-FGF-23 ANTIBODY

Publication Number WO/2012/055096
Publication Date 03.05.2012
International Application No. PCT/CN2010/078143
International Filing Date 27.10.2010
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07K 16/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 14/50 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
50Fibroblast growth factor (FGF)
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
C07K 16/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
22against growth factors ; ; against growth regulators
G01N 2333/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
475Assays involving growth factors
50Fibroblast growth factors [FGF]
G01N 2800/347
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
34Genitourinary disorders
347Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
G01N 33/6893
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6893related to diseases not provided for elsewhere
Applicants
  • 温州医学院生物与天然药物开发中心有限公司 WENZHOU MEDICAL INSTITUTE BIOLOGICAL AND NATURAL DRUG DEVELOPMENT CENTER CO., LTD. [CN]/[CN] (AllExceptUS)
  • 李校堃 LI, Xiaokun [CN]/[CN] (UsOnly)
  • 刘孝菊 LIU, Xiaoju [CN]/[CN] (UsOnly)
Inventors
  • 李校堃 LI, Xiaokun
  • 刘孝菊 LIU, Xiaoju
Agents
  • 上海智信专利代理有限公司 SHANGHAI ZHI XIN PATENT AGENT LTD.
Priority Data
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PREPARATION METHOD AND USE OF ANTI-FGF-23 ANTIBODY
(FR) PROCÉDÉ DE PRÉPARATION ET UTILISATION D'ANTICORPS ANTI-FGF-23
(ZH) 抗FGF-23抗体的制备方法及用途
Abstract
(EN)
The present invention discloses a method for preparing a monoclonal antibody against fibroblast growth factor-23 (FGF-23) with a fusion protein, which comprises a glutathione-S-transferase and a 73-amino acid fragment at C-terminus of FGF-23, and a use of the antibody prepared by this method in diagnosing chronic renal diseases.
(FR)
La présente invention concerne un procédé de préparation d'un anticorps monoclonal contre le facteur de croissance fibroblastique 23 (FGF-23) avec une protéine de fusion, qui comprend une glutathion-S-transférase et un fragment de 73 acides aminés à l'extrémité C-terminale de FGF-23, et une utilisation de l'anticorps préparé par ce procédé dans le diagnostic de maladies rénales chroniques.
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