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1. (WO2012054988) SELENO-COMPOUNDS AND THERAPEUTIC USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/054988 International Application No.: PCT/AU2011/001391
Publication Date: 03.05.2012 International Filing Date: 28.10.2011
IPC:
C07D 345/00 (2006.01) ,A61P 25/28 (2006.01) ,C07H 5/08 (2006.01) ,A61K 31/33 (2006.01) ,A61P 35/00 (2006.01) ,A61P 9/10 (2006.01) ,A61P 39/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
345
Heterocyclic compounds containing rings having selenium or tellurium atoms as the only ring hetero atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
5
Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
08
to sulfur, selenium, or tellurium
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39
General protective or antinoxious agents
06
Free radical scavengers or antioxidants
Applicants:
THE UNIVERSITY OF MELBOURNE [AU/AU]; 205-211 Grattan Street Carlton, Victoria 3053, AU (AllExceptUS)
THE HEART RESEARCH INSTITUTE [AU/AU]; 7 Eliza Street Newtown, New South Wales 2042, AU (AllExceptUS)
SCHIESSER, Carl Herbert [AU/AU]; AU (UsOnly)
STORKEY, Corin [NZ/AU]; AU (UsOnly)
DAVIES, Michael Jonathan [AU/AU]; AU (UsOnly)
Inventors:
SCHIESSER, Carl Herbert; AU
STORKEY, Corin; AU
DAVIES, Michael Jonathan; AU
Agent:
LUCAS, Mathew, A; Davies Collison Cave 1 Nicholson Street Melbourne, Victoria 3000, AU
Priority Data:
201090480128.10.2010AU
Title (EN) SELENO-COMPOUNDS AND THERAPEUTIC USES THEREOF
(FR) COMPOSÉS SÉLÉNO ET LEURS UTILISATIONS THÉRAPEUTIQUES
Abstract:
(EN) The present invention relates to compounds and compositions useful as antioxidants and in particular to selenium containing compounds of formula (I): wherein n is 1, 2, or 3; m is 2, 3, 4, or 5; and each R] is independently -(optionally substituted C 1 -C3 alkylene) p-OH, where p is 0 or 1, or a salt thereof. The invention also relates to the use of these seleno-compounds in the treatment of diseases or conditions associated with increased levels of oxidants produced by myeloperoxidase (MPO), such as for instance, atherosclerosis.
(FR) La présente invention concerne des composés et des compositions utiles en tant qu'antioxydants et en particulier des composés contenant du sélénium de formule (I) : dans laquelle n vaut 1, 2 ou 3 ; m vaut 2, 3, 4 ou 5 ; et chaque R] représente indépendamment -(alkylène en C1 à C3 éventuellement substitué) p-OH, où p vaut 0 ou 1, ou l'un de leurs sels. L'invention concerne également l'utilisation de ces composés séléno dans le traitement de maladies ou d'affections associées à des taux accrus d'oxydants produits par la myéloperoxydase (MPO), comme par exemple, l'athérosclérose.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20140206658US20150191446