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1. WO2012054874 - NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION

Publication Number WO/2012/054874
Publication Date 26.04.2012
International Application No. PCT/US2011/057352
International Filing Date 21.10.2011
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
407
condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4184
condensed with carbocyclic rings, e.g. benzimidazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
08
Tripeptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
428
condensed with carbocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517
ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
C07D 487/04 (2006.01)
A61P 31/14 (2006.01)
A61K 31/407 (2006.01)
A61K 31/4184 (2006.01)
A61K 31/44 (2006.01)
C07K 5/08 (2006.01)
CPC
C07K 5/0804
C12N 9/99
Applicants
  • INTERMUNE, INC. [US/US]; 3280 Bayshore Boulevard Brisbane, CA 94005, US (AllExceptUS)
  • BUCKMAN, Brad [US/US]; US (UsOnly)
  • SEREBRYANY, Vladimir [US/US]; US (UsOnly)
  • NICHOLAS, John, B. [US/US]; US (UsOnly)
  • SEIWERT, Scott [US/US]; US (UsOnly)
Inventors
  • BUCKMAN, Brad; US
  • SEREBRYANY, Vladimir; US
  • NICHOLAS, John, B.; US
  • SEIWERT, Scott; US
Agents
  • HART, Daniel; Knobbe Martens Olson & Bear LLP 2040 Main Street 14th Floor Irvine, CA 92614, US
Priority Data
61/406,05822.10.2010US
61/473,56808.04.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION
(FR) NOUVEAUX INHIBITEURS MACROCYCLIQUES DE LA RÉPLICATION DU VIRUS DE L'HÉPATITE C
Abstract
(EN)
The embodiments provide compounds of the general Formulae I, la, II, Ila, IIΙ, IIIa, IV, IVa, V, Va, VI and VIa, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
(FR)
Les modes de réalisation de l'invention concernent des composés de Formules générales I, la, II, Ila, IIΙ, IIIa, IV, IVa, V, Va, VI et VIa, ainsi que des compositions, notamment des compositions pharmaceutiques, comprenant le composé de l'invention. Les modes de réalisation concernent en outre des méthodes de traitement, notamment des méthodes de traitement d'une infection par le virus de l'hépatite C, et des méthodes de traitement d'une fibrose hépatique, les méthodes consistant généralement à administrer une quantité efficace d'un composé ou d'une composition de l'invention à un individu en ayant besoin.
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