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1. (WO2012054723) TREATMENT OF ALPHA-L-IDURONIDASE (IDUA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IDUA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/054723    International Application No.:    PCT/US2011/057097
Publication Date: 26.04.2012 International Filing Date: 20.10.2011
IPC:
C12N 15/113 (2010.01), C12Q 1/68 (2006.01), C12N 15/63 (2006.01), A61K 31/7088 (2006.01), A61K 48/00 (2006.01)
Applicants: CURNA INC. [US/US]; 4400 Biscayne Blvd. Miami, Florida 33137 (US) (For All Designated States Except US).
COLLARD, Joseph [US/US]; (US) (For US Only).
KHORKOVA SHERMAN, Olga [US/US]; (US) (For US Only).
COITO, Carlos [PT/US]; (US) (For US Only).
Gang, Shen [CN/US]; (US) (For US Only)
Inventors: COLLARD, Joseph; (US).
KHORKOVA SHERMAN, Olga; (US).
COITO, Carlos; (US).
Gang, Shen; (US)
Agent: BROWDER, Monte, R.; 4400 Biscayne Blvd. Miami, Florida 33137 (US)
Priority Data:
61/405,758 22.10.2010 US
Title (EN) TREATMENT OF ALPHA-L-IDURONIDASE (IDUA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IDUA
(FR) TRAITEMENT DE MALADIES ASSOCIÉES À L'ALPHA-L-IDURONIDASE (IDUA) PAR INHIBITION DU TRANSCRIT ANTISENS ENDOGÈNE DE IDUA
Abstract: front page image
(EN)The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Alpha-L-Iduronidase (IDUA), in particular, by targeting natural antisense polynucleotides of Alpha-L-Iduronidase (IDUA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IDUA.
(FR)La présente invention concerne des oligonucléotides antisens qui modulent l'expression et/ou la fonction de l'alpha-L-iduronidase (IDUA), en particulier, par le ciblage des polynucléotides antisens endogènes de l'alpha-L-iduronidase (IDUA). L'invention concerne également l'identification de ces oligonucléotides antisens, et leur utilisation dans le traitement de maladies et de troubles associés à l'expression de IDUA.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)